Multifunctional iron-based Metal−Organic framework as biodegradable nanozyme for microwave enhancing dynamic therapy

Xiaoyan Ma, Xiangling Ren, Xudong Guo, Changhui Fu, Qiong Wu, Longfei Tan, Hongbo Li, Wei Zhang, Xudong Chen, Hongshan Zhong, Xianwei Meng*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

150 Citations (Scopus)

Abstract

Nanozymes with excellent enzyme-mimicking catalytic property are playing an increasingly significant role in tumor diagnosis and therapy. Fe-metal organic framework nanoparticles (MIL-101(Fe) NPs) are prepared as nanozymes to generate reactive oxygen species (ROS) and induce cancer cell death by catalyzing endogenous substances in tumor microenvironment. Abundant stimuli-responsive hydroxyl radicals (·OH) are accelerated to generate in the presence of microwave irradiation, realizing microwave enhancing dynamic therapy (MEDT). Moreover, MIL-101(Fe) NPs possess biodegradability and bioresponsibility, which exhibit favourable properties of metabolism and non-toxic accumulation comparing with inorganic nanozymes. Fluorescent gold nanoclusters (BSA-Au NCs) are rapidly coupled with the surface of MIL-101(Fe) NPs to obtain MIL-101(Fe)@BSA-AuNCs NPs. MIL-101(Fe)@BSA-AuNCs NPs with magnetic resonance imaging (MRI) and fluorescent imaging (FI) not only image accurately for the site of tumor, but also monitor dynamic distribution process of MIL-101(Fe) in vivo. The signal intensity of FI and MRI reaches maximum at 1 h in the liver and 5 h in the tumor. Ionic liquid (IL) is also loaded into MIL-101(Fe)@BSA-AuNCs NPs as microwave sensitive reagents for microwave thermal therapy (MTT). This work synthesizes the nanozymes that possess degradability, microwave sensitivity and dual-mode imaging to achieve the combination of MTT and MEDT against tumor. Experiment result in vivo confirms that the kill rate of tumor is up to 96.65%, showing an outstanding anti-tumor efficacy.

Original languageEnglish
Article number119223
JournalBiomaterials
Volume214
DOIs
Publication statusPublished - Sept 2019

Keywords

  • Cancer therapy
  • Enzyme mimics
  • Metal-organic framework
  • Microwave
  • Nanozyme

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