TY - GEN
T1 - Morphologic and functional connectivity alterations in patients with major depressive disorder
AU - Yang, Yang
AU - Hu, Changqing
AU - Imamura, Kazuyuki
AU - Yang, Xiaojing
AU - Li, Huaizhou
AU - Wang, Gang
AU - Feng, Lei
AU - Hu, Bin
AU - Lu, Shengfu
AU - Zhong, Ning
N1 - Publisher Copyright:
© Springer International Publishing Switzerland 2015.
PY - 2015
Y1 - 2015
N2 - In order to obtain a panorama of structural and functional brain abnormalities as well as the association between the anatomic and functional alterations and clinical symptoms in patients with major depressive disorder (MDD), integrated magnetic resonance imaging (MRI) measures were implemented on 21 MDD patients and 21 healthy controls, to facilitate the multimodality of voxel-based morphometry (VBM) analysis, resting-state functional connectivity analysis, and symptom rating. MDD patients showed significantly decreased gray matter volume (GMV) in the rostral part of anterior cingulate cortex (rACC), precuneus, and superior parietal lobule in the right hemisphere. By using the above morphologic deficits areas as seed regions, functional connectivity analysis revealed reduced coupling in the limbic-cortical and frontoparietal networks, respectively. Subsequent correlation analyses revealed that GMV in the rACC negatively correlated with the depressive symptom severity and anxiety level. Our findings provide evidence supporting both morphologic and functional deficits in the limbic-cortical and frontal-parietal areas in MDD patients which could account for their dysfunctions on emotional regulation and cognition. Moreover, the neural changes found in rACC could be possible state markers for evaluating effects of anti-depressive treatment and anxiety level.
AB - In order to obtain a panorama of structural and functional brain abnormalities as well as the association between the anatomic and functional alterations and clinical symptoms in patients with major depressive disorder (MDD), integrated magnetic resonance imaging (MRI) measures were implemented on 21 MDD patients and 21 healthy controls, to facilitate the multimodality of voxel-based morphometry (VBM) analysis, resting-state functional connectivity analysis, and symptom rating. MDD patients showed significantly decreased gray matter volume (GMV) in the rostral part of anterior cingulate cortex (rACC), precuneus, and superior parietal lobule in the right hemisphere. By using the above morphologic deficits areas as seed regions, functional connectivity analysis revealed reduced coupling in the limbic-cortical and frontoparietal networks, respectively. Subsequent correlation analyses revealed that GMV in the rACC negatively correlated with the depressive symptom severity and anxiety level. Our findings provide evidence supporting both morphologic and functional deficits in the limbic-cortical and frontal-parietal areas in MDD patients which could account for their dysfunctions on emotional regulation and cognition. Moreover, the neural changes found in rACC could be possible state markers for evaluating effects of anti-depressive treatment and anxiety level.
UR - http://www.scopus.com/inward/record.url?scp=84945966142&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-23344-4_4
DO - 10.1007/978-3-319-23344-4_4
M3 - Conference contribution
AN - SCOPUS:84945966142
SN - 9783319233437
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 33
EP - 42
BT - Brain Informatics and Health - 8th International Conference, BIH 2015, Proceedings
A2 - Guo Y., Yike
A2 - Hill S., Sean
A2 - Friston, Karl
A2 - Peng, Hanchuan
A2 - Faisal A., Aldo
PB - Springer Verlag
T2 - 8th International Conference on Brain Informatics and Health, BIH 2015
Y2 - 30 August 2015 through 2 September 2015
ER -