Individual functional parcellation revealed compensation of dynamic limbic network organization in healthy ageing

Tiantian Liu, Zhongyan Shi, Jian Zhang, Kexin Wang, Yuanhao Li, Guangying Pei*, Li Wang, Jinglong Wu, Tianyi Yan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Using group-level functional parcellations and constant-length sliding window analysis, dynamic functional connectivity studies have revealed network-specific impairment and compensation in healthy ageing. However, functional parcellation and dynamic time windows vary across individuals; individual-level ageing-related brain dynamics are uncertain. Here, we performed individual parcellation and individual-length sliding window clustering to characterize ageing-related dynamic network changes. Healthy participants (n = 637, 18–88 years) from the Cambridge Centre for Ageing and Neuroscience dataset were included. An individual seven-network parcellation, varied from group-level parcellation, was mapped for each participant. For each network, strong and weak cognitive brain states were revealed by individual-length sliding window clustering and canonical correlation analysis. The results showed negative linear correlations between age and change ratios of sizes in the default mode, frontoparietal, and salience networks and a positive linear correlation between age and change ratios of size in the limbic network (LN). With increasing age, the occurrence and dwell time of strong states showed inverted U-shaped patterns or a linear decreasing pattern in most networks but showed a linear increasing pattern in the LN. Overall, this study reveals a compensative increase in emotional networks (i.e., the LN) and a decline in cognitive and primary sensory networks in healthy ageing. These findings may provide insights into network-specific and individual-level targeting during neuromodulation in ageing and ageing-related diseases.

Original languageEnglish
Pages (from-to)744-761
Number of pages18
JournalHuman Brain Mapping
Volume44
Issue number2
DOIs
Publication statusPublished - 1 Feb 2023

Keywords

  • brain states
  • clustering
  • dynamic functional connectivity
  • individual sliding window
  • resting-state fMRI

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