Gold nanoparticles bearing a clinically used non-antibiotic drug for combating multi-drug resistant bacteria

Yuexiao Jia; Jiangjiang Zhang; Yingcan Zhao; Ruihua Dong; Hui Wang; Xingyu Jiang

doi:10.1039/d2cc03460c

Gold nanoparticles bearing a clinically used non-antibiotic drug for combating multi-drug resistant bacteria

Yuexiao Jia, Jiangjiang Zhang, Yingcan Zhao, Ruihua Dong, Hui Wang, Xingyu Jiang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We introduce N-acetyl-l-cysteine (NAC), a clinically used non-antibiotic drug, to the synthesis of antibacterial gold nanoparticles (Au_NAC). Au_NAC shows excellent antibacterial activities against multi-drug resistant (MDR) Gram-negative bacteria and possesses wound healing capabilities. We provide a new direction for antibiotic design and novel uses of known drugs.

Original language	English
Pages (from-to)	10544-10547
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	75
DOIs	https://doi.org/10.1039/d2cc03460c
Publication status	Published - 11 Aug 2022
Externally published	Yes

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10.1039/d2cc03460c

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title = "Gold nanoparticles bearing a clinically used non-antibiotic drug for combating multi-drug resistant bacteria",

abstract = "We introduce N-acetyl-l-cysteine (NAC), a clinically used non-antibiotic drug, to the synthesis of antibacterial gold nanoparticles (Au_NAC). Au_NAC shows excellent antibacterial activities against multi-drug resistant (MDR) Gram-negative bacteria and possesses wound healing capabilities. We provide a new direction for antibiotic design and novel uses of known drugs.",

author = "Yuexiao Jia and Jiangjiang Zhang and Yingcan Zhao and Ruihua Dong and Hui Wang and Xingyu Jiang",

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AU - Jia, Yuexiao

AU - Zhang, Jiangjiang

AU - Zhao, Yingcan

AU - Dong, Ruihua

AU - Wang, Hui

AU - Jiang, Xingyu

PY - 2022/8/11

Y1 - 2022/8/11

N2 - We introduce N-acetyl-l-cysteine (NAC), a clinically used non-antibiotic drug, to the synthesis of antibacterial gold nanoparticles (Au_NAC). Au_NAC shows excellent antibacterial activities against multi-drug resistant (MDR) Gram-negative bacteria and possesses wound healing capabilities. We provide a new direction for antibiotic design and novel uses of known drugs.

AB - We introduce N-acetyl-l-cysteine (NAC), a clinically used non-antibiotic drug, to the synthesis of antibacterial gold nanoparticles (Au_NAC). Au_NAC shows excellent antibacterial activities against multi-drug resistant (MDR) Gram-negative bacteria and possesses wound healing capabilities. We provide a new direction for antibiotic design and novel uses of known drugs.

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M3 - Article

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VL - 58

SP - 10544

EP - 10547

JO - Chemical Communications

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ER -

Gold nanoparticles bearing a clinically used non-antibiotic drug for combating multi-drug resistant bacteria

Abstract

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