Ferrocene-Encapsulated Zn Zeolitic Imidazole Framework (ZIF-8) for Optical and Electrochemical Sensing of Amyloid-β Oligomers and for the Early Diagnosis of Alzheimer's Disease

Jieling Qin, Misuk Cho*, Youngkwan Lee

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

88 Citations (Scopus)

Abstract

In this work, the ferrocene-encapsulated Zn zeolitic imidazole framework (ZIF-8) was prepared by the self-assembly of Zn ions and 2-methylimidazole and used for the dual detection of amyloid-beta oligomers (AβO), which is the main neuropathological hallmark of Alzheimer's disease. Ferrocene is an optically and electrochemically active signal which was successfully encapsulated inside of the ZIF-8 and released by the competitive coordination between Zn ions and AβO after being treated with AβO. The released ferrocene content was monitored by ultraviolet/visible spectrophotometry and cyclic voltammetry. The dual determination of AβO played a synergetic role in the quick qualitative and precise quantitative analyses in a wide detection range of 10 -5 to 10 2 μM and good feasibility in artificial cerebrospinal fluid.

Original languageEnglish
Pages (from-to)11743-11748
Number of pages6
JournalACS applied materials & interfaces
Volume11
Issue number12
DOIs
Publication statusPublished - 27 Mar 2019
Externally publishedYes

Keywords

  • ZIF-8
  • alzheimer's disease
  • amyloid beta
  • dual detection
  • ferrocene

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