Abstract
Aim: To investigate the effect of transient ischemia attack(TIA) on phospholipid level and the effect of traditional Chinese herb - Yangxueqingnao particles. Methods: To establish the animal model of TIA in mice by injecting Peroxide through caudal vein, and then feed the mice with Yangxueqingnao particles in different dose. After evoking 4 times of TIA and cut off the head the other day, then measure the level of lysophosphatidic acid(LPA), general phospholipid in blood plasma and brain tissue. Results: Score of the group without treatment was 1.0 ± 0.8, while that of group administered with Yangxueqingnao particles(2 g/kg) was 0.5 ± 0.4(P < 0.05) LPA level of TIA mice were 6.1 ± 0.4 and 2.1 ± 1.3 and increased significantly compared with that of the control. This changes can be reversed by treatment as can be seen the result 4.9 ± 1.6. general phospholipid level of TIA mice in brain tissue decreased significantly compared with that of the control as the result: (2.3 ± 1.1) and (6.6 ± 2.8) μmol/g, respectively. After treatment, general phopholipid level can reach (4.3 ± 2.0) μmol/g. Conclusion: LPA and general phospholipid levels in blood plasma and brain tissue are abnormal in experimental TIA mice, but can be reversed by Yangxueqingnao particles and it can be used in treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 500-501 |
| Number of pages | 2 |
| Journal | Chinese Journal of Clinical Rehabilitation |
| Volume | 7 |
| Issue number | 3 |
| Publication status | Published - Feb 2003 |
| Externally published | Yes |
Keywords
- Ischemic attack
- Patent drugs
- Phosphotidylethanolamines
- Ready-made
- Transient