Abstract
Enantioselective Friedel-Crafts alkylation reactions of indoles with β,γ-unsaturated α-ketoesters catalyzed by novel chiral C 2-symmetric squaramide-linked bisoxazoline-Zn(OTf)2 complexes were investigated. The corresponding indole ketoesters were obtained in good to excellent yields (up to 98%) and with high enantioselectivities (up to 94% ee). This is the first report on the use of chiral squaramide-linked bisoxazoline SQBOX in a catalytic enanitioselective Friedel-Crafts alkylation reaction.
Original language | English |
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Pages (from-to) | 980-988 |
Number of pages | 9 |
Journal | Tetrahedron Asymmetry |
Volume | 25 |
Issue number | 13-14 |
DOIs | |
Publication status | Published - 31 Jul 2014 |
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Jia, S. J., & Du, D. M. (2014). Enantioselective Friedel-Crafts alkylation of indoles with β,γ-unsaturated α-ketoesters catalyzed by new squaramide-linked bisoxazoline-Zn(OTf)2 complexes. Tetrahedron Asymmetry, 25(13-14), 980-988. https://doi.org/10.1016/j.tetasy.2014.05.011