Effect of drageny I on blood rheology and oxidative damage of myocardium in rats under simulated microgravity

Yu Juan Li*, Bo Chen, Lin Gan, Tie Gao, Jin Yuan Qiao, Yu Lin Deng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

It is the first time to investigate effects, on the blood rheology and the protection on oxidative damage in myocardium in tail-suspended rats of Drageny I, which is a kind of rare TCM herbs. SD rats are randomly divided into three groups: control group, model group and drug group. The blood rheology and the oxidative damage (the level of H2O2, MDA and T-SOD) of myocardium are examined in ways as follows: veinal blood and myocardium test after 5 d and 21 d tail-suspension respectively. Compared with the model group, the hematocrit and the level of myocardium MDA in drug group decrease significantly after 5 d of tail-suspension. Red blood cell maximum deformation index, whole blood viscosity, the level of H2O2 and T-SOD of myocardium show no significant changes. After 21 d of tail-suspension, whole blood viscosity of the drug group decreases significantly while red blood cell maximum deformation index increases remarkably. Other indexes show recovery tendency. Drageny I significantly inhibits the increase in hematocrit and blood viscosity while increasing the red blood cell maximum deformation index in tail-suspended rats. It also shows protective effects on the myocardium from oxidative stress in rats under the simulated microgravity condition.

Original languageEnglish
Pages (from-to)1313-1316
Number of pages4
JournalBeijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
Volume33
Issue number12
Publication statusPublished - Dec 2013

Keywords

  • Blood rheology
  • Drageny I
  • Oxidative stress
  • Simulated microgravity

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