Dual-Functional Supernanoparticles with Microwave Dynamic Therapy and Microwave Thermal Therapy

Qiong Wu, Na Xia, Dan Long, Longfei Tan, Wei Rao, Jie Yu, Changhui Fu, Xiangling Ren, Hongbo Li, Li Gou, Ping Liang*, Jun Ren, Laifeng Li, Xianwei Meng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

120 Citations (Scopus)

Abstract

The cytotoxic reactive oxygen species (ROS) generated by photoactivated sensitizers have been well explored in tumor therapy for nearly half a century, which is known as photodynamic therapy (PDT). The poor light penetration depth severely hinders PDT as a primary or adjuvant therapy for clinical indication. Whereas microwaves (MWs) are advantageous for deep penetration depth, the MW energy is considerably lower than that required for the activation of any species to induce ROS generation. Herein we find that liquid metal (LM) supernanoparticles activated by MW irradiation can generate ROS, such as ·OH and ·O2. On this basis, we design dual-functional supernanoparticles by loading LMs and an MW heating sensitizer ionic liquid (IL) into mesoporous ZrO2 nanoparticles, which can be activated by MW as the sole energy source for dynamic and thermal therapy concomitantly. The microwave sensitizer opens the door to an entirely novel dynamic treatment for tumors.

Original languageEnglish
Pages (from-to)5277-5286
Number of pages10
JournalNano Letters
Volume19
Issue number8
DOIs
Publication statusPublished - 14 Aug 2019

Keywords

  • Liquid metals
  • microwave dynamic therapy
  • microwave thermal therapy
  • supernanoparticles

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