Carrier-free photosensitizer nanocrystal for photodynamic therapy

Fei Fei An; Yanan Li; Jinfeng Zhang

doi:10.1016/j.matlet.2014.02.067

Carrier-free photosensitizer nanocrystal for photodynamic therapy

Fei Fei An^*, Yanan Li, Jinfeng Zhang

^*Corresponding author for this work

CAS - Technical Institute of Physics and Chemistry

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

In recent years, many nanomaterials have been developed as drug carriers to overcome their low solubility. However, the poor drug loading (general <5%) requires excessive use of carrier materials which may induce side effects and inhibit their clinical translation. Herein, hydrophobic meso- tetraphenylporphyrin (TPP) photosensitizer (PS) molecules are firstly assembled into pure nanocrystals by solvent exchange. Secondly, amphiphilic multidentate polymer ligand, PEG-grafted poly (maleic anhydride-alt-1-octadecene) (C ₁₈PMH-PEG), is modified on the nanocrystal surface to enhance their stability in saline. The as-prepared drug delivery system (DDS) by the two-step strategy significantly improves the drug loading (over 87%). The DDS shows high stability in saline and is engulfed by cancer cells. Further study demonstrates that the DDS is an effective photodynamic therapeutic agent of cancer cells while the free PS molecules quickly precipitate without obvious destruction of cancer cells.

Original language	English
Pages (from-to)	323-326
Number of pages	4
Journal	Materials Letters
Volume	122
DOIs	https://doi.org/10.1016/j.matlet.2014.02.067
Publication status	Published - 1 May 2014
Externally published	Yes

Keywords

Biomaterials
Drug loading
Luminescence
Nanoparticles
Photodynamic therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.matlet.2014.02.067

Cite this

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title = "Carrier-free photosensitizer nanocrystal for photodynamic therapy",

abstract = "In recent years, many nanomaterials have been developed as drug carriers to overcome their low solubility. However, the poor drug loading (general <5%) requires excessive use of carrier materials which may induce side effects and inhibit their clinical translation. Herein, hydrophobic meso- tetraphenylporphyrin (TPP) photosensitizer (PS) molecules are firstly assembled into pure nanocrystals by solvent exchange. Secondly, amphiphilic multidentate polymer ligand, PEG-grafted poly (maleic anhydride-alt-1-octadecene) (C 18PMH-PEG), is modified on the nanocrystal surface to enhance their stability in saline. The as-prepared drug delivery system (DDS) by the two-step strategy significantly improves the drug loading (over 87%). The DDS shows high stability in saline and is engulfed by cancer cells. Further study demonstrates that the DDS is an effective photodynamic therapeutic agent of cancer cells while the free PS molecules quickly precipitate without obvious destruction of cancer cells.",

keywords = "Biomaterials, Drug loading, Luminescence, Nanoparticles, Photodynamic therapy",

author = "An, {Fei Fei} and Yanan Li and Jinfeng Zhang",

year = "2014",

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doi = "10.1016/j.matlet.2014.02.067",

language = "English",

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AU - An, Fei Fei

AU - Li, Yanan

AU - Zhang, Jinfeng

PY - 2014/5/1

Y1 - 2014/5/1

N2 - In recent years, many nanomaterials have been developed as drug carriers to overcome their low solubility. However, the poor drug loading (general <5%) requires excessive use of carrier materials which may induce side effects and inhibit their clinical translation. Herein, hydrophobic meso- tetraphenylporphyrin (TPP) photosensitizer (PS) molecules are firstly assembled into pure nanocrystals by solvent exchange. Secondly, amphiphilic multidentate polymer ligand, PEG-grafted poly (maleic anhydride-alt-1-octadecene) (C 18PMH-PEG), is modified on the nanocrystal surface to enhance their stability in saline. The as-prepared drug delivery system (DDS) by the two-step strategy significantly improves the drug loading (over 87%). The DDS shows high stability in saline and is engulfed by cancer cells. Further study demonstrates that the DDS is an effective photodynamic therapeutic agent of cancer cells while the free PS molecules quickly precipitate without obvious destruction of cancer cells.

AB - In recent years, many nanomaterials have been developed as drug carriers to overcome their low solubility. However, the poor drug loading (general <5%) requires excessive use of carrier materials which may induce side effects and inhibit their clinical translation. Herein, hydrophobic meso- tetraphenylporphyrin (TPP) photosensitizer (PS) molecules are firstly assembled into pure nanocrystals by solvent exchange. Secondly, amphiphilic multidentate polymer ligand, PEG-grafted poly (maleic anhydride-alt-1-octadecene) (C 18PMH-PEG), is modified on the nanocrystal surface to enhance their stability in saline. The as-prepared drug delivery system (DDS) by the two-step strategy significantly improves the drug loading (over 87%). The DDS shows high stability in saline and is engulfed by cancer cells. Further study demonstrates that the DDS is an effective photodynamic therapeutic agent of cancer cells while the free PS molecules quickly precipitate without obvious destruction of cancer cells.

KW - Biomaterials

KW - Drug loading

KW - Luminescence

KW - Nanoparticles

KW - Photodynamic therapy

UR - http://www.scopus.com/inward/record.url?scp=84896535678&partnerID=8YFLogxK

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DO - 10.1016/j.matlet.2014.02.067

M3 - Article

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SN - 0167-577X

VL - 122

SP - 323

EP - 326

JO - Materials Letters

JF - Materials Letters

ER -

Carrier-free photosensitizer nanocrystal for photodynamic therapy

Abstract

Keywords

UN SDGs

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