C-Reactive Protein Causes Adult-Onset Obesity Through Chronic Inflammatory Mechanism

Qiling Li; Qi Wang; Wei Xu; Yamin Ma; Qing Wang; Danita Eatman; Shaojin You; Jin Zou; James Champion; Lanbo Zhao; Ye Cui; Wenzhi Li; Yangyang Deng; Li Ma; Biao Wu; Guangdi Wang; Xiaodong Zhang; Qingwei Wang; Mohamed A. Bayorh; Qing Song

doi:10.3389/fcell.2020.00018

C-Reactive Protein Causes Adult-Onset Obesity Through Chronic Inflammatory Mechanism

Qiling Li^*, Qi Wang, Wei Xu, Yamin Ma, Qing Wang, Danita Eatman, Shaojin You, Jin Zou, James Champion, Lanbo Zhao, Ye Cui, Wenzhi Li, Yangyang Deng, Li Ma, Biao Wu, Guangdi Wang, Xiaodong Zhang, Qingwei Wang, Mohamed A. Bayorh, Qing Song

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Obesity is characterized by low-grade chronic inflammation. As an acute-phase reactant to inflammation and infection, C-reactive protein (CRP) has been found to be the strongest factor associated with obesity. Here we show that chronic elevation of human CRP at baseline level causes the obesity. The obesity phenotype is confirmed by whole-body magnetic resonance imaging (MRI), in which the total fat mass is 6- to 9- fold higher in the CRP rats than the control rats. Univariate linear regression analysis showed different growth rates between the CRP rats and the control rats, and that the difference appears around 11 weeks old, indicating that they developed adult-onset obesity. We also found that chronic elevation of CRP can prime molecular changes broadly in the innate immune system, energy expenditure systems, thyroid hormones, apolipoproteins, and gut flora. Our data established a causal role of CRP elevation in the development of adult-onset obesity.

Original language	English
Article number	18
Journal	Frontiers in Cell and Developmental Biology
Volume	8
DOIs	https://doi.org/10.3389/fcell.2020.00018
Publication status	Published - 20 Feb 2020
Externally published	Yes

Keywords

CRP
adult-onset
gut flora
inflammation
obesity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3389/fcell.2020.00018

Cite this

Li, Q., Wang, Q., Xu, W., Ma, Y., Wang, Q., Eatman, D., You, S., Zou, J., Champion, J., Zhao, L., Cui, Y., Li, W., Deng, Y., Ma, L., Wu, B., Wang, G., Zhang, X., Wang, Q., Bayorh, M. A., & Song, Q. (2020). C-Reactive Protein Causes Adult-Onset Obesity Through Chronic Inflammatory Mechanism. Frontiers in Cell and Developmental Biology, 8, Article 18. https://doi.org/10.3389/fcell.2020.00018

@article{77da8416893d427dbc7018093e91e373,

title = "C-Reactive Protein Causes Adult-Onset Obesity Through Chronic Inflammatory Mechanism",

abstract = "Obesity is characterized by low-grade chronic inflammation. As an acute-phase reactant to inflammation and infection, C-reactive protein (CRP) has been found to be the strongest factor associated with obesity. Here we show that chronic elevation of human CRP at baseline level causes the obesity. The obesity phenotype is confirmed by whole-body magnetic resonance imaging (MRI), in which the total fat mass is 6- to 9- fold higher in the CRP rats than the control rats. Univariate linear regression analysis showed different growth rates between the CRP rats and the control rats, and that the difference appears around 11 weeks old, indicating that they developed adult-onset obesity. We also found that chronic elevation of CRP can prime molecular changes broadly in the innate immune system, energy expenditure systems, thyroid hormones, apolipoproteins, and gut flora. Our data established a causal role of CRP elevation in the development of adult-onset obesity.",

keywords = "CRP, adult-onset, gut flora, inflammation, obesity",

author = "Qiling Li and Qi Wang and Wei Xu and Yamin Ma and Qing Wang and Danita Eatman and Shaojin You and Jin Zou and James Champion and Lanbo Zhao and Ye Cui and Wenzhi Li and Yangyang Deng and Li Ma and Biao Wu and Guangdi Wang and Xiaodong Zhang and Qingwei Wang and Bayorh, {Mohamed A.} and Qing Song",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2020 Li, Wang, Xu, Ma, Wang, Eatman, You, Zou, Champion, Zhao, Cui, Li, Deng, Ma, Wu, Wang, Zhang, Wang, Bayorh and Song.",

year = "2020",

month = feb,

day = "20",

doi = "10.3389/fcell.2020.00018",

language = "English",

volume = "8",

journal = "Frontiers in Cell and Developmental Biology",

issn = "2296-634X",

publisher = "Frontiers Media SA",

}

TY - JOUR

T1 - C-Reactive Protein Causes Adult-Onset Obesity Through Chronic Inflammatory Mechanism

AU - Li, Qiling

AU - Wang, Qi

AU - Xu, Wei

AU - Ma, Yamin

AU - Wang, Qing

AU - Eatman, Danita

AU - You, Shaojin

AU - Zou, Jin

AU - Champion, James

AU - Zhao, Lanbo

AU - Cui, Ye

AU - Li, Wenzhi

AU - Deng, Yangyang

AU - Ma, Li

AU - Wu, Biao

AU - Wang, Guangdi

AU - Zhang, Xiaodong

AU - Wang, Qingwei

AU - Bayorh, Mohamed A.

AU - Song, Qing

PY - 2020/2/20

Y1 - 2020/2/20

N2 - Obesity is characterized by low-grade chronic inflammation. As an acute-phase reactant to inflammation and infection, C-reactive protein (CRP) has been found to be the strongest factor associated with obesity. Here we show that chronic elevation of human CRP at baseline level causes the obesity. The obesity phenotype is confirmed by whole-body magnetic resonance imaging (MRI), in which the total fat mass is 6- to 9- fold higher in the CRP rats than the control rats. Univariate linear regression analysis showed different growth rates between the CRP rats and the control rats, and that the difference appears around 11 weeks old, indicating that they developed adult-onset obesity. We also found that chronic elevation of CRP can prime molecular changes broadly in the innate immune system, energy expenditure systems, thyroid hormones, apolipoproteins, and gut flora. Our data established a causal role of CRP elevation in the development of adult-onset obesity.

AB - Obesity is characterized by low-grade chronic inflammation. As an acute-phase reactant to inflammation and infection, C-reactive protein (CRP) has been found to be the strongest factor associated with obesity. Here we show that chronic elevation of human CRP at baseline level causes the obesity. The obesity phenotype is confirmed by whole-body magnetic resonance imaging (MRI), in which the total fat mass is 6- to 9- fold higher in the CRP rats than the control rats. Univariate linear regression analysis showed different growth rates between the CRP rats and the control rats, and that the difference appears around 11 weeks old, indicating that they developed adult-onset obesity. We also found that chronic elevation of CRP can prime molecular changes broadly in the innate immune system, energy expenditure systems, thyroid hormones, apolipoproteins, and gut flora. Our data established a causal role of CRP elevation in the development of adult-onset obesity.

KW - CRP

KW - adult-onset

KW - gut flora

KW - inflammation

KW - obesity

UR - http://www.scopus.com/inward/record.url?scp=85081210123&partnerID=8YFLogxK

U2 - 10.3389/fcell.2020.00018

DO - 10.3389/fcell.2020.00018

M3 - Article

AN - SCOPUS:85081210123

SN - 2296-634X

VL - 8

JO - Frontiers in Cell and Developmental Biology

JF - Frontiers in Cell and Developmental Biology

M1 - 18

ER -

C-Reactive Protein Causes Adult-Onset Obesity Through Chronic Inflammatory Mechanism

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this