Bioinspired Hierarchical Self-Assembled Nanozyme for Efficient Antibacterial Treatment

Ningning Song, Yue Yu, Yinuo Zhang, Zhengdi Wang, Zhanjun Guo, Jianlin Zhang, Changbin Zhang*, Minmin Liang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

Along with the rapid development and ever-deepening understanding of nanoscience and nanotechnology, nanomaterials hold promise to mimic the highly evolved biological exquisite nanostructures and sophisticated functions. Here, inspired by the ubiquitous antibacterial nanostructures on the wing surfaces of some insects, a NiCo2O4 nanozyme with self-adaptive hierarchical nanostructure is developed that can capture bacteria of various morphotypes via the physico-mechanical interaction between the nanostructure and bacteria. Moreover, the developed biomimetic nanostructure further exhibits superior peroxidase-like catalytic activity, which can catalytically generate highly toxic reactive oxygen species that disrupt bacterial membranes and induce bacterial apoptosis. Therefore, the mechano-catalytic coupling property of this NiCo2O4 nanozyme allows for an extensive and efficient antibacterial application, with no concerns of antimicrobial resistance. This work suggests a promising strategy for the rational design of advanced antibacterial materials by mimicking biological antibiosis.

Original languageEnglish
Article number2210455
JournalAdvanced Materials
Volume36
Issue number10
DOIs
Publication statusPublished - 7 Mar 2024

Keywords

  • NiCo O
  • antibacterial treatment
  • mechano-catalytic coupling behavior
  • nanozyme
  • self-adaptive structure

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