Application of the hydroxypropyl cellulose-graft-polycaprolactone copolymer in drug microencapsulation

Chenggong Guo; Liang Wang; Caiqi Wang; Huimin Tan; Yuping Dong

Application of the hydroxypropyl cellulose-graft-polycaprolactone copolymer in drug microencapsulation

Chenggong Guo, Liang Wang, Caiqi Wang^*, Huimin Tan, Yuping Dong

^*Corresponding author for this work

School of Material Science and Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

The hydroxypropyl cellulose-graft-polycaprolactone (HPC-g-PCL) microcapsules containing lysozyme were prepared by the solvent extraction method based on the formation of multiple W/O/W emulsion. The size distribution of the microspheres was in the range of 1 μm~10 μm determined by laser analysis. The existence of lysozme was confirmed by FT-IR. And the crystallinity and the melting temperature decrease due to the introduction of lysozyme, according to the results of DSC. The scanning election microscope (SEM) reveals that the HPC-g-PCL microcapsules have shriveled appearance compared with PCL microcapsules. This means that the surface areas of the microspheres increase and are more easily to contact with the water molecules.

Original language	English
Pages (from-to)	110-113
Number of pages	4
Journal	Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering
Volume	28
Issue number	10
Publication status	Published - Oct 2012

Keywords

Graft copolymer
Hydroxypropyl cellulose-graft-polycaprolactone
Lysozyme
Microencapsulations
ε-caprolactone

Cite this

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title = "Application of the hydroxypropyl cellulose-graft-polycaprolactone copolymer in drug microencapsulation",

abstract = "The hydroxypropyl cellulose-graft-polycaprolactone (HPC-g-PCL) microcapsules containing lysozyme were prepared by the solvent extraction method based on the formation of multiple W/O/W emulsion. The size distribution of the microspheres was in the range of 1 μm~10 μm determined by laser analysis. The existence of lysozme was confirmed by FT-IR. And the crystallinity and the melting temperature decrease due to the introduction of lysozyme, according to the results of DSC. The scanning election microscope (SEM) reveals that the HPC-g-PCL microcapsules have shriveled appearance compared with PCL microcapsules. This means that the surface areas of the microspheres increase and are more easily to contact with the water molecules.",

keywords = "Graft copolymer, Hydroxypropyl cellulose-graft-polycaprolactone, Lysozyme, Microencapsulations, ε-caprolactone",

author = "Chenggong Guo and Liang Wang and Caiqi Wang and Huimin Tan and Yuping Dong",

year = "2012",

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TY - JOUR

T1 - Application of the hydroxypropyl cellulose-graft-polycaprolactone copolymer in drug microencapsulation

AU - Guo, Chenggong

AU - Wang, Liang

AU - Wang, Caiqi

AU - Tan, Huimin

AU - Dong, Yuping

PY - 2012/10

Y1 - 2012/10

N2 - The hydroxypropyl cellulose-graft-polycaprolactone (HPC-g-PCL) microcapsules containing lysozyme were prepared by the solvent extraction method based on the formation of multiple W/O/W emulsion. The size distribution of the microspheres was in the range of 1 μm~10 μm determined by laser analysis. The existence of lysozme was confirmed by FT-IR. And the crystallinity and the melting temperature decrease due to the introduction of lysozyme, according to the results of DSC. The scanning election microscope (SEM) reveals that the HPC-g-PCL microcapsules have shriveled appearance compared with PCL microcapsules. This means that the surface areas of the microspheres increase and are more easily to contact with the water molecules.

AB - The hydroxypropyl cellulose-graft-polycaprolactone (HPC-g-PCL) microcapsules containing lysozyme were prepared by the solvent extraction method based on the formation of multiple W/O/W emulsion. The size distribution of the microspheres was in the range of 1 μm~10 μm determined by laser analysis. The existence of lysozme was confirmed by FT-IR. And the crystallinity and the melting temperature decrease due to the introduction of lysozyme, according to the results of DSC. The scanning election microscope (SEM) reveals that the HPC-g-PCL microcapsules have shriveled appearance compared with PCL microcapsules. This means that the surface areas of the microspheres increase and are more easily to contact with the water molecules.

KW - Graft copolymer

KW - Hydroxypropyl cellulose-graft-polycaprolactone

KW - Lysozyme

KW - Microencapsulations

KW - ε-caprolactone

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M3 - Article

AN - SCOPUS:84870270532

SN - 1000-7555

VL - 28

SP - 110

EP - 113

JO - Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering

JF - Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering

IS - 10

ER -

Application of the hydroxypropyl cellulose-graft-polycaprolactone copolymer in drug microencapsulation

Abstract

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