Aldehyde-Assisted Ruthenium(II)-Catalyzed C-H Oxygenations

Fanzhi Yang; Karsten Rauch; Katharina Kettelhoit; Lutz Ackermann

doi:10.1002/anie.201405647

Aldehyde-Assisted Ruthenium(II)-Catalyzed C-H Oxygenations

Fanzhi Yang, Karsten Rauch, Katharina Kettelhoit, Lutz Ackermann^*

^*Corresponding author for this work

University of Göttingen

Research output: Contribution to journal › Article › peer-review

163 Citations (Scopus)

Abstract

Versatile ruthenium(II) complexes allow for site-selective C-H oxygenations with weakly-coordinating aldehydes. The challenging C-H functionalizations proceed with high chemoselectivity by rate-determining C-H metalation. The new method features an ample substrate scope, which sets the stage for the step-economical preparation of various bioactive heterocycles.

Original language	English
Pages (from-to)	11285-11288
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	53
Issue number	42
DOIs	https://doi.org/10.1002/anie.201405647
Publication status	Published - 13 Oct 2014
Externally published	Yes

Keywords

C-H activation
aldehydes
chemoselectivity
oxygenation
ruthenium

Access to Document

10.1002/anie.201405647

Cite this

@article{f09d222f09604ab69d0c1cec943910b7,

title = "Aldehyde-Assisted Ruthenium(II)-Catalyzed C-H Oxygenations",

abstract = "Versatile ruthenium(II) complexes allow for site-selective C-H oxygenations with weakly-coordinating aldehydes. The challenging C-H functionalizations proceed with high chemoselectivity by rate-determining C-H metalation. The new method features an ample substrate scope, which sets the stage for the step-economical preparation of various bioactive heterocycles.",

keywords = "C-H activation, aldehydes, chemoselectivity, oxygenation, ruthenium",

author = "Fanzhi Yang and Karsten Rauch and Katharina Kettelhoit and Lutz Ackermann",

note = "Publisher Copyright: {\textcopyright} 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2014",

month = oct,

day = "13",

doi = "10.1002/anie.201405647",

language = "English",

volume = "53",

pages = "11285--11288",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "42",

}

TY - JOUR

T1 - Aldehyde-Assisted Ruthenium(II)-Catalyzed C-H Oxygenations

AU - Yang, Fanzhi

AU - Rauch, Karsten

AU - Kettelhoit, Katharina

AU - Ackermann, Lutz

PY - 2014/10/13

Y1 - 2014/10/13

N2 - Versatile ruthenium(II) complexes allow for site-selective C-H oxygenations with weakly-coordinating aldehydes. The challenging C-H functionalizations proceed with high chemoselectivity by rate-determining C-H metalation. The new method features an ample substrate scope, which sets the stage for the step-economical preparation of various bioactive heterocycles.

AB - Versatile ruthenium(II) complexes allow for site-selective C-H oxygenations with weakly-coordinating aldehydes. The challenging C-H functionalizations proceed with high chemoselectivity by rate-determining C-H metalation. The new method features an ample substrate scope, which sets the stage for the step-economical preparation of various bioactive heterocycles.

KW - C-H activation

KW - aldehydes

KW - chemoselectivity

KW - oxygenation

KW - ruthenium

UR - http://www.scopus.com/inward/record.url?scp=85027937992&partnerID=8YFLogxK

U2 - 10.1002/anie.201405647

DO - 10.1002/anie.201405647

M3 - Article

AN - SCOPUS:85027937992

SN - 1433-7851

VL - 53

SP - 11285

EP - 11288

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 42

ER -

Aldehyde-Assisted Ruthenium(II)-Catalyzed C-H Oxygenations

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this