Aldehyde-Assisted Ruthenium(II)-Catalyzed C-H Oxygenations

Fanzhi Yang; Karsten Rauch; Katharina Kettelhoit; Lutz Ackermann

doi:10.1002/anie.201405647

Aldehyde-Assisted Ruthenium(II)-Catalyzed C-H Oxygenations

Fanzhi Yang, Karsten Rauch, Katharina Kettelhoit, Lutz Ackermann^*

^*Corresponding author for this work

University of Göttingen

Research output: Contribution to journal › Article › peer-review

166 Citations (Scopus)

Abstract

Versatile ruthenium(II) complexes allow for site-selective C-H oxygenations with weakly-coordinating aldehydes. The challenging C-H functionalizations proceed with high chemoselectivity by rate-determining C-H metalation. The new method features an ample substrate scope, which sets the stage for the step-economical preparation of various bioactive heterocycles.

Original language	English
Pages (from-to)	11285-11288
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	53
Issue number	42
DOIs	https://doi.org/10.1002/anie.201405647
Publication status	Published - 13 Oct 2014
Externally published	Yes

Keywords

C-H activation
aldehydes
chemoselectivity
oxygenation
ruthenium

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10.1002/anie.201405647

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Yang, F., Rauch, K., Kettelhoit, K., & Ackermann, L. (2014). Aldehyde-Assisted Ruthenium(II)-Catalyzed C-H Oxygenations. Angewandte Chemie - International Edition, 53(42), 11285-11288. https://doi.org/10.1002/anie.201405647

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KW - C-H activation

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Aldehyde-Assisted Ruthenium(II)-Catalyzed C-H Oxygenations

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Keywords

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