Adaptive amphiphilic dendrimer-based nanoassemblies as robust and versatile siRNA delivery systems

Xiaoxuan Liu, Jiehua Zhou, Tianzhu Yu, Chao Chen, Qiang Cheng, Kheya Sengupta, Yuanyu Huang, Haitang Li, Cheng Liu, Yang Wang, Paola Posocco, Menghua Wang, Qi Cui, Suzanne Giorgio, Maurizio Fermeglia, Fanqi Qu, Sabrina Pricl, Yanhong Shi, Zicai Liang, Palma RocchiJohn J. Rossi, Ling Peng

Research output: Contribution to journalArticlepeer-review

182 Citations (Scopus)

Abstract

siRNA delivery remains a major challenge in RNAi-based therapy. Here, we report for the first time that an amphiphilic dendrimer is able to self-assemble into adaptive supramolecular assemblies upon interaction with siRNA, and effectively delivers siRNAs to various cell lines, including human primary and stem cells, thereby outperforming the currently available nonviral vectors. In addition, this amphi-philic dendrimer is able to harness the advantageous features of both polymer and lipid vectors and hence promotes effective siRNA delivery. Our study demonstrates for the first time that dendrimer-based adaptive supramolecular assemblies represent novel and versatile means for functional siRNA delivery, heralding a new age of dendrimer-based self-assembled drug delivery in biomedical applications.

Original languageEnglish
Pages (from-to)11822-11827
Number of pages6
JournalAngewandte Chemie - International Edition
Volume53
Issue number44
DOIs
Publication statusPublished - 27 Oct 2014
Externally publishedYes

Keywords

  • Dendrimers
  • Gene silencing
  • Nanocarriers
  • Nonviral vectors
  • Self-assembly

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