A reticuloendothelial system-stealthy dye-albumin nanocomplex as a highly biocompatible and highly luminescent nanoprobe for targeted in vivo tumor imaging

Fei Fei An, Yin Long Yang, Juan Liu, Jun Ye, Jin Feng Zhang, Meng Jiao Zhou, Xiu Juan Zhang, Cai Jun Zheng, Xing Jie Liang, Xiao Hong Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

A reticuloendothelial system (RES)-stealthy nanoprobe for enhanced tumor imaging is a longstanding pursuit. In this study, a nanocomplex comprising albumin and dye is assembled without crosslinker use. The nanocomplex shows intense luminescence with a photoluminescence quantum yield of up to 0.39 and a large Stokes shift of >130 nm. The nanocomplex also exhibits higher stability against hydrolysis than indocyanine green during the 14 days test. The nanocomplex shows favourable high biocompatibility and can be used for cell labelling. Remarkably, the nanocomplex exhibits six times higher tumor accumulation than that in the liver and spleen. At 96 h post-injection, the nanoprobe is still observable and gives a clear imaging of tumors, which can help in convenient diagnosis post-injection.

Original languageEnglish
Pages (from-to)6120-6126
Number of pages7
JournalRSC Advances
Volume4
Issue number12
DOIs
Publication statusPublished - 2014
Externally publishedYes

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