TY - JOUR
T1 - A Bifunctional Aggregation-Induced Emission Luminogen for Monitoring and Killing of Multidrug-Resistant Bacteria
AU - Li, Ying
AU - Zhao, Zheng
AU - Zhang, Jiangjiang
AU - Kwok, Ryan T.K.
AU - Xie, Sheng
AU - Tang, Rongbing
AU - Jia, Yuexiao
AU - Yang, Junchuan
AU - Wang, Le
AU - Lam, Jacky W.Y.
AU - Zheng, Wenfu
AU - Jiang, Xingyu
AU - Tang, Ben Zhong
N1 - Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2018/10/17
Y1 - 2018/10/17
N2 - Multidrug-resistant (MDR) bacteria pose serious threats to public health as there is currently a lack of effective and biocompatible drugs to kill MDR bacteria. Here, a bifunctional aggregation-induced emission luminogen (AIEgen), triphenylethylene-naphthalimide triazole (TriPE-NT), is reported, which is capable of both staining and killing Gram-positive (G+) and Gram-negative (G−) bacteria. The intrinsic fluorescence generating ability of the TriPE unit enables TriPE-NT to monitor the drug–bacteria interactions, meanwhile, the NT unit renders TriPE-NT the antibacterial activity. Furthermore, TriPE-NT can generate reactive oxygen species (ROS) under light irradiation and drastically enhance its antibacterial efficacy by photodynamic therapy against wild bacteria and clinical isolated MDR bacteria with a very low toxicity to mammalian cells. Moreover, the efficiency of TriPE-NT staining on bacteria closely correlates with its antibacterial efficacy. As an example of application, TriPE-NT is utilized in curing Escherichia coli- (E. coli), MDR E. coli-, Staphylococcus epidermidis- (S. epidermidis), and MDR S. epidermidis- infected wounds on rats with high efficacy and high safety. Thus, TriPE-NT can be used not only as a powerful antibiotic agent for treating MDR bacteria-infected diseases but also as a potential fluorescent agent for monitoring the bacterial infections and further exploring the related antibacterial mechanism.
AB - Multidrug-resistant (MDR) bacteria pose serious threats to public health as there is currently a lack of effective and biocompatible drugs to kill MDR bacteria. Here, a bifunctional aggregation-induced emission luminogen (AIEgen), triphenylethylene-naphthalimide triazole (TriPE-NT), is reported, which is capable of both staining and killing Gram-positive (G+) and Gram-negative (G−) bacteria. The intrinsic fluorescence generating ability of the TriPE unit enables TriPE-NT to monitor the drug–bacteria interactions, meanwhile, the NT unit renders TriPE-NT the antibacterial activity. Furthermore, TriPE-NT can generate reactive oxygen species (ROS) under light irradiation and drastically enhance its antibacterial efficacy by photodynamic therapy against wild bacteria and clinical isolated MDR bacteria with a very low toxicity to mammalian cells. Moreover, the efficiency of TriPE-NT staining on bacteria closely correlates with its antibacterial efficacy. As an example of application, TriPE-NT is utilized in curing Escherichia coli- (E. coli), MDR E. coli-, Staphylococcus epidermidis- (S. epidermidis), and MDR S. epidermidis- infected wounds on rats with high efficacy and high safety. Thus, TriPE-NT can be used not only as a powerful antibiotic agent for treating MDR bacteria-infected diseases but also as a potential fluorescent agent for monitoring the bacterial infections and further exploring the related antibacterial mechanism.
KW - AIEgen
KW - antimicrobial agents
KW - bacterial infections
KW - reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=85052811612&partnerID=8YFLogxK
U2 - 10.1002/adfm.201804632
DO - 10.1002/adfm.201804632
M3 - Article
AN - SCOPUS:85052811612
SN - 1616-301X
VL - 28
JO - Advanced Functional Materials
JF - Advanced Functional Materials
IS - 42
M1 - 1804632
ER -
