α-and β-N-furanoribosyl amide: Synthesis and purification

Mu Hua Huang; Yong Chen Gao; Feng Ling Yang; Yun Jun Luo

α-and β-N-furanoribosyl amide: Synthesis and purification

Mu Hua Huang^*, Yong Chen Gao, Feng Ling Yang, Yun Jun Luo

^*Corresponding author for this work

School of Material Science and Engineering

Zhengzhou University

Research output: Contribution to journal › Article › peer-review

Abstract

In order to disclose the role of N-glycosyl amides-containing proteins in the life process, an efficient separation and purification of α-/β-isomers were urgently required. This paper reported a synthesis and purification of two pairs of α-/β-furanoribosyl amide, 6a/6b and 9a/9b. The results show the important role of basic developing solvents to separate α-and β-isomers by thin layer chromatography (TLC). And a high ΔR_f of 0.24 between α- and β-isomers (9a/9b) are achieved, which lead to their easy peperation by flash column chromatography.

Original language	English
Pages (from-to)	1085-1089
Number of pages	5
Journal	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
Volume	34
Issue number	10
Publication status	Published - 1 Oct 2014

Keywords

Epimers
Furanoside
N-glycopeptide
N-glycosyl amide
Seperation

Cite this

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abstract = "In order to disclose the role of N-glycosyl amides-containing proteins in the life process, an efficient separation and purification of α-/β-isomers were urgently required. This paper reported a synthesis and purification of two pairs of α-/β-furanoribosyl amide, 6a/6b and 9a/9b. The results show the important role of basic developing solvents to separate α-and β-isomers by thin layer chromatography (TLC). And a high ΔRf of 0.24 between α- and β-isomers (9a/9b) are achieved, which lead to their easy peperation by flash column chromatography.",

keywords = "Epimers, Furanoside, N-glycopeptide, N-glycosyl amide, Seperation",

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T2 - Synthesis and purification

AU - Huang, Mu Hua

AU - Gao, Yong Chen

AU - Yang, Feng Ling

AU - Luo, Yun Jun

PY - 2014/10/1

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N2 - In order to disclose the role of N-glycosyl amides-containing proteins in the life process, an efficient separation and purification of α-/β-isomers were urgently required. This paper reported a synthesis and purification of two pairs of α-/β-furanoribosyl amide, 6a/6b and 9a/9b. The results show the important role of basic developing solvents to separate α-and β-isomers by thin layer chromatography (TLC). And a high ΔRf of 0.24 between α- and β-isomers (9a/9b) are achieved, which lead to their easy peperation by flash column chromatography.

AB - In order to disclose the role of N-glycosyl amides-containing proteins in the life process, an efficient separation and purification of α-/β-isomers were urgently required. This paper reported a synthesis and purification of two pairs of α-/β-furanoribosyl amide, 6a/6b and 9a/9b. The results show the important role of basic developing solvents to separate α-and β-isomers by thin layer chromatography (TLC). And a high ΔRf of 0.24 between α- and β-isomers (9a/9b) are achieved, which lead to their easy peperation by flash column chromatography.

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KW - Furanoside

KW - N-glycopeptide

KW - N-glycosyl amide

KW - Seperation

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ER -

α-and β-N-furanoribosyl amide: Synthesis and purification

Abstract

Keywords

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