Research output per year
Research output per year
Personal profile
Personal profile
Ni Junjun, male, born in 1988, PhD, Special Researcher/Pre-appointed Associate Professor
Email: nijunjun@bit.edu.cn
Office Address: 609 Building 5, Beijing Institute of Technology
Ni Junjun, male, born in 1988, PhD, Special Researcher/Pre-appointed Associate Professor
Email: nijunjun@bit.edu.cn
Office Address: 609 Building 5, Beijing Institute of Technology
Ni Junjun, male, born in 1988, PhD, Special Researcher/Pre-appointed Associate Professor
Email: nijunjun@bit.edu.cn
Office Address: 609 Building 5, Beijing Institute of Technology
Research Interests
1. Molecular mechanisms of aging and neurodegenerative diseases;
2. Study on pathological function of cathepsin family;
3. Study on the immune characteristics of microglia under physiological and pathological conditions;
4. Study on the relationship and mechanism between oral diseases and brain cognitive function.
1. Molecular mechanisms of aging and neurodegenerative diseases;
2. Study on pathological function of cathepsin family;
3. Study on the immune characteristics of microglia under physiological and pathological conditions;
4. Study on the relationship and mechanism between oral diseases and brain cognitive function.
Education
2012.10-2016.3 Kyushu University, School of Dentistry, Geriatrics and Pharmacology, PhD,
2010.9-2012.7 Master of Neurobiology, School of Life Sciences, Beijing Institute of Technology,
2006.9-2010.7 Biotechnology, College of Medicine, Qingdao University
Professional Experience
2019.11-present, Beijing Institute of Technology, School of Life Sciences, Special Researcher
2016.3-2019.10 Assistant Professor of Gerontology and Pharmacology, Kyushu University, School of Dentistry
2019.11-present, Beijing Institute of Technology, School of Life Sciences, Special Researcher
2016.3-2019.10 Assistant Professor of Gerontology and Pharmacology, Kyushu University, School of Dentistry
Research Achievement
1. National Natural Science Foundation of China, Surface Project, 32070954, Microglia and Neuronal tissue proteinase B involved in the pathogenesis of Alzheimer's Disease, 2021-2024-12, 580,000 yuan, ongoing research, Host.
2. Beijing Municipal Science and Technology Commission, Surface Project, 7212066, The role and mechanism of cathepsin B in regulating neuronal function in Alzheimer's Disease, 2021-2023-12, 200,000 yuan, Ongoing research, Host.
3. Beijing Institute of Technology, Science and Technology Innovation Program, 2020CX04166, The role and mechanism of cathepsin E in regulating microglia function in Alzheimer's Disease, 2020-1 to 2022-12, 600,000 yuan, Ongoing research, Host.
4. Japan Academic Promotion Association, Young Scholars Research Fund, JP17K17093, The role of cathepsins in Aβ degradation in Alzheimer's -like disease, 2017-4 to 2019-3, 4.16 million yen (274,000 yuan), closed, host.
5. Japan Association for The Promotion of Academia, Challenging Budding Fund, JP18K19650, The effects of gingipain on the pathogenesis of Alzheimer's disease, 2018-6 to 2021-3, 6.37 million yen (390,000 yuan), completed, participate.
6. National Natural Science Foundation of China, Surface Project, 81171206, Study on the regulation of β-secretase (BACE1) by Premature aging Factor and the pathogenesis of Alzheimer's Disease, 2012-01 to 2015-12,600 million yuan, completed, participated.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A mixture of extracts from natural ingredients reduces the neurotoxic polarization of microglia via modulating NF-κB/NF-E2-related factor 2 activation
Gui, S., Ni, J., Mizutani, S., Shigematsu, N., Nakanishi, H., Kashiwazaki, H. & Wu, Z., May 2024, In: Food Science and Nutrition. 12, 5, p. 3745-3758 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Cathepsin B modulates microglial migration and phagocytosis of amyloid β in Alzheimer’s disease through PI3K-Akt signaling
Jiang, M., Zhao, D., Zhou, Y., Kong, W., Xie, Z., Xiong, Y., Li, Y., Zhao, S., Kou, X., Zhang, S., Meng, R., Pan, Y., Wu, Z., Nakanishi, H., Zhao, J., Li, H., Quan, Z., Lin, L., Qing, H. & Ni, J., 2024, (Accepted/In press) In: Neuropsychopharmacology.Research output: Contribution to journal › Article › peer-review
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Clusterin is a Potential Therapeutic Target in Alzheimer’s Disease
Palihati, N., Tang, Y., Yin, Y., Yu, D., Liu, G., Quan, Z., Ni, J., Yan, Y. & Qing, H., Jul 2024, In: Molecular Neurobiology. 61, 7, p. 3836-3850 15 p.Research output: Contribution to journal › Review article › peer-review
2 Citations (Scopus) -
Emerging Roles of Microglia in Blood-Brain Barrier Integrity in Aging and Neurodegeneration
Zhang, S., Meng, R., Jiang, M., Qing, H. & Ni, J., 2024, In: Current Neuropharmacology. 22, 7, p. 1189-1204 16 p.Research output: Contribution to journal › Review article › peer-review
1 Citation (Scopus) -
Extracellular Matrix Remodeling Alleviates Memory Deficits in Alzheimer's Disease by Enhancing the Astrocytic Autophagy-Lysosome Pathway
Yang, Q., Yan, C., Sun, Y., Xie, Z., Yang, L., Jiang, M., Ni, J., Chen, B., Xu, S., Yuan, Z., Wu, Y., Liu, X., Yuan, Z. & Bai, Z., 21 Aug 2024, In: Advanced Science. 11, 31, 2400480.Research output: Contribution to journal › Article › peer-review
Open Access