TY - GEN
T1 - X2-Gait
T2 - 2025 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2025
AU - Gao, Haoran
AU - Zhang, Shuo
AU - Lu, Chenyang
AU - Zhang, Zengyu
AU - Li, Qi
AU - Zhang, Yanan
AU - Shen, Jian
AU - Hu, Bin
N1 - Publisher Copyright:
© 2025 IEEE.
PY - 2025
Y1 - 2025
N2 - Early subthreshold depression identification is critical for intervention but hampered by subjective assessments. Gait analysis offers a promising objective biomarker, but existing computational methods struggle to integrate multi-scale motor patterns and lack the interpretability required for clinical trust. This paper introduces X2-Gait, a novel deep learning framework designed to address these challenges. X2-Gait pioneers a hierarchical, context-aware mechanism that extracts features at multiple granularities, from fine-grained joint kinematics to holistic body posture. Crucially, it designates macro-level postural features as a 'contextual anchor' to dynamically guide the interpretation of micro-level movement features via a gating network. This architecture uniquely enables dual-level interpretability, providing both a high-level postural assessment and specific, corroborating biomechanical evidence for each prediction. Evaluated on a dataset of individuals with subthreshold depression and healthy controls, X2-Gait not only achieves state-of-theart classification accuracy (70.26%) but also generates clinically meaningful, hierarchical explanations. This work represents a significant step toward developing transparent, trustworthy, and non-intrusive tools for mental health screening.
AB - Early subthreshold depression identification is critical for intervention but hampered by subjective assessments. Gait analysis offers a promising objective biomarker, but existing computational methods struggle to integrate multi-scale motor patterns and lack the interpretability required for clinical trust. This paper introduces X2-Gait, a novel deep learning framework designed to address these challenges. X2-Gait pioneers a hierarchical, context-aware mechanism that extracts features at multiple granularities, from fine-grained joint kinematics to holistic body posture. Crucially, it designates macro-level postural features as a 'contextual anchor' to dynamically guide the interpretation of micro-level movement features via a gating network. This architecture uniquely enables dual-level interpretability, providing both a high-level postural assessment and specific, corroborating biomechanical evidence for each prediction. Evaluated on a dataset of individuals with subthreshold depression and healthy controls, X2-Gait not only achieves state-of-theart classification accuracy (70.26%) but also generates clinically meaningful, hierarchical explanations. This work represents a significant step toward developing transparent, trustworthy, and non-intrusive tools for mental health screening.
UR - https://www.scopus.com/pages/publications/105033609649
U2 - 10.1109/BIBM66473.2025.11356147
DO - 10.1109/BIBM66473.2025.11356147
M3 - Conference contribution
AN - SCOPUS:105033609649
T3 - Proceedings - 2025 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2025
SP - 1659
EP - 1664
BT - Proceedings - 2025 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2025
A2 - Liu, Juan
A2 - Huang, Jingshan
A2 - Wang, Xiaowo
A2 - Zhang, Fa
A2 - Zou, Xiufen
A2 - Tian, Tian
A2 - Hu, Xiaohua
A2 - Hu, Bin
A2 - Xiong, Yi
PB - Institute of Electrical and Electronics Engineers Inc.
Y2 - 15 December 2025 through 18 December 2025
ER -