Water-Soluble Polythiophene for Two-Photon Excitation Fluorescence Imaging and Photodynamic Therapy of Cancer

Minhuan Lan; Shaojing Zhao; Yusheng Xie; Junfang Zhao; Liang Guo; Guangle Niu; Ying Li; Hongyan Sun; Hongyan Zhang; Weimin Liu; Jinyuan Zhang; Pengfei Wang; Wenjun Zhang

doi:10.1021/acsami.6b15537

Water-Soluble Polythiophene for Two-Photon Excitation Fluorescence Imaging and Photodynamic Therapy of Cancer

Minhuan Lan
, Shaojing Zhao
, Yusheng Xie
, Junfang Zhao
, Liang Guo
, Guangle Niu
, Ying Li
, Hongyan Sun
, Hongyan Zhang
, Weimin Liu
, Jinyuan Zhang
, Pengfei Wang^*
, Wenjun Zhang

^*此作品的通讯作者

City University of Hong Kong
CAS - Technical Institute of Physics and Chemistry
University of Chinese Academy of Sciences

科研成果: 期刊稿件 › 文章 › 同行评审

52 引用（Scopus）

摘要

Positively charged water-soluble polythiophene (PT0) that could self-assemble into nanoparticles in pure water solution was designed and synthesized. PT0 exhibited high photostabilities and pH stabilities, excellent biocompatibility, strong ¹O₂ generation capability, and large two-photon absorption cross sections. Moreover, we showed that the fluorescence of PT0 was unaffected by the interference of biomolecules and metal ions. As an example application, PT0 was demonstrated to be capable of simultaneous cell imaging and photodynamic therapy under either one-photon or two-photon excitation modes.

源语言	英语
页（从-至）	14590-14595
页数	6
期刊	ACS Applied Materials and Interfaces
卷	9
期	17
DOI	https://doi.org/10.1021/acsami.6b15537
出版状态	已出版 - 3 5月 2017
已对外发布	是

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉

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10.1021/acsami.6b15537

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title = "Water-Soluble Polythiophene for Two-Photon Excitation Fluorescence Imaging and Photodynamic Therapy of Cancer",

abstract = "Positively charged water-soluble polythiophene (PT0) that could self-assemble into nanoparticles in pure water solution was designed and synthesized. PT0 exhibited high photostabilities and pH stabilities, excellent biocompatibility, strong 1O2 generation capability, and large two-photon absorption cross sections. Moreover, we showed that the fluorescence of PT0 was unaffected by the interference of biomolecules and metal ions. As an example application, PT0 was demonstrated to be capable of simultaneous cell imaging and photodynamic therapy under either one-photon or two-photon excitation modes.",

keywords = "PDT, conjugated polymer, fluorescence imaging, two photon",

author = "Minhuan Lan and Shaojing Zhao and Yusheng Xie and Junfang Zhao and Liang Guo and Guangle Niu and Ying Li and Hongyan Sun and Hongyan Zhang and Weimin Liu and Jinyuan Zhang and Pengfei Wang and Wenjun Zhang",

note = "Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

year = "2017",

month = may,

day = "3",

doi = "10.1021/acsami.6b15537",

language = "English",

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TY - JOUR

T1 - Water-Soluble Polythiophene for Two-Photon Excitation Fluorescence Imaging and Photodynamic Therapy of Cancer

AU - Lan, Minhuan

AU - Zhao, Shaojing

AU - Xie, Yusheng

AU - Zhao, Junfang

AU - Guo, Liang

AU - Niu, Guangle

AU - Li, Ying

AU - Sun, Hongyan

AU - Zhang, Hongyan

AU - Liu, Weimin

AU - Zhang, Jinyuan

AU - Wang, Pengfei

AU - Zhang, Wenjun

PY - 2017/5/3

Y1 - 2017/5/3

N2 - Positively charged water-soluble polythiophene (PT0) that could self-assemble into nanoparticles in pure water solution was designed and synthesized. PT0 exhibited high photostabilities and pH stabilities, excellent biocompatibility, strong 1O2 generation capability, and large two-photon absorption cross sections. Moreover, we showed that the fluorescence of PT0 was unaffected by the interference of biomolecules and metal ions. As an example application, PT0 was demonstrated to be capable of simultaneous cell imaging and photodynamic therapy under either one-photon or two-photon excitation modes.

AB - Positively charged water-soluble polythiophene (PT0) that could self-assemble into nanoparticles in pure water solution was designed and synthesized. PT0 exhibited high photostabilities and pH stabilities, excellent biocompatibility, strong 1O2 generation capability, and large two-photon absorption cross sections. Moreover, we showed that the fluorescence of PT0 was unaffected by the interference of biomolecules and metal ions. As an example application, PT0 was demonstrated to be capable of simultaneous cell imaging and photodynamic therapy under either one-photon or two-photon excitation modes.

KW - PDT

KW - conjugated polymer

KW - fluorescence imaging

KW - two photon

UR - https://www.scopus.com/pages/publications/85018986296

U2 - 10.1021/acsami.6b15537

DO - 10.1021/acsami.6b15537

M3 - Article

C2 - 28401752

AN - SCOPUS:85018986296

SN - 1944-8244

VL - 9

SP - 14590

EP - 14595

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 17

ER -

Water-Soluble Polythiophene for Two-Photon Excitation Fluorescence Imaging and Photodynamic Therapy of Cancer

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