Targeting peptide-mediated nanoparticle transport and antitumor efficacy research based on spatial proteomics

Limin Zhang; Zhiwei Yin; Minxuan Wang; Beilei Sun; Bo Wang; Kai Han; Jinge Zhao; Mingshan Wei; Jingrui Deng; Weizhi Wang

doi:10.1039/d6cc02928k

Targeting peptide-mediated nanoparticle transport and antitumor efficacy research based on spatial proteomics

Limin Zhang
, Zhiwei Yin
, Minxuan Wang
, Beilei Sun
, Bo Wang
, Kai Han
, Jinge Zhao
, Mingshan Wei
, Jingrui Deng
, Weizhi Wang^*

^*此作品的通讯作者

The University of Hong Kong
Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

摘要

Nanoparticle-based drugs face challenges of weak spatiotemporal control and difficulty in elucidating their mechanisms of action. We designed a stimulus-responsive delivery system based on targeted peptides and quantum dots (QDs) to achieve synergistic therapy combining sonodynamic therapy (SDT) and immune checkpoint blockade (ICB). Using spatially resolved proteomics technology, we analyzed the mechanism underlying this synergy.

源语言	英语
期刊	Chemical Communications
DOI	https://doi.org/10.1039/d6cc02928k
出版状态	已接受/待刊 - 2026
已对外发布	是

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title = "Targeting peptide-mediated nanoparticle transport and antitumor efficacy research based on spatial proteomics",

abstract = "Nanoparticle-based drugs face challenges of weak spatiotemporal control and difficulty in elucidating their mechanisms of action. We designed a stimulus-responsive delivery system based on targeted peptides and quantum dots (QDs) to achieve synergistic therapy combining sonodynamic therapy (SDT) and immune checkpoint blockade (ICB). Using spatially resolved proteomics technology, we analyzed the mechanism underlying this synergy.",

author = "Limin Zhang and Zhiwei Yin and Minxuan Wang and Beilei Sun and Bo Wang and Kai Han and Jinge Zhao and Mingshan Wei and Jingrui Deng and Weizhi Wang",

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doi = "10.1039/d6cc02928k",

language = "English",

journal = "Chemical Communications",

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TY - JOUR

T1 - Targeting peptide-mediated nanoparticle transport and antitumor efficacy research based on spatial proteomics

AU - Zhang, Limin

AU - Yin, Zhiwei

AU - Wang, Minxuan

AU - Sun, Beilei

AU - Wang, Bo

AU - Han, Kai

AU - Zhao, Jinge

AU - Wei, Mingshan

AU - Deng, Jingrui

AU - Wang, Weizhi

PY - 2026

Y1 - 2026

N2 - Nanoparticle-based drugs face challenges of weak spatiotemporal control and difficulty in elucidating their mechanisms of action. We designed a stimulus-responsive delivery system based on targeted peptides and quantum dots (QDs) to achieve synergistic therapy combining sonodynamic therapy (SDT) and immune checkpoint blockade (ICB). Using spatially resolved proteomics technology, we analyzed the mechanism underlying this synergy.

AB - Nanoparticle-based drugs face challenges of weak spatiotemporal control and difficulty in elucidating their mechanisms of action. We designed a stimulus-responsive delivery system based on targeted peptides and quantum dots (QDs) to achieve synergistic therapy combining sonodynamic therapy (SDT) and immune checkpoint blockade (ICB). Using spatially resolved proteomics technology, we analyzed the mechanism underlying this synergy.

UR - https://www.scopus.com/pages/publications/105045346588

U2 - 10.1039/d6cc02928k

DO - 10.1039/d6cc02928k

M3 - Article

AN - SCOPUS:105045346588

SN - 1359-7345

JO - Chemical Communications

JF - Chemical Communications

ER -

Targeting peptide-mediated nanoparticle transport and antitumor efficacy research based on spatial proteomics

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