Synthesis of [18O2]-curcumin

Xiurui Shen; Xiaomei Yang; Ying Zhu; Xihuan Liu; Hongliang Wen

doi:10.1002/jlcr.3238

Synthesis of [¹⁸O₂]-curcumin

Xiurui Shen
, Xiaomei Yang
, Ying Zhu
, Xihuan Liu
, Hongliang Wen^*

^*此作品的通讯作者

化学与化工学院

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

2 引用（Scopus）

摘要

Curcumin, a pigment isolated from rhizomes of Curcuma longa, is a potent cancer chemopreventive and chemotherapeutic agent and is now evaluated in phase III human clinical trials. This report describes an efficient synthesis of [¹⁸O₂]-curcumin. [¹⁸O₂]-Curcumin was prepared in three steps from 1-iodo-2-methoxy-4-methylbenzene in an overall yield of 53%.

源语言	英语
页（从-至）	658-659
页数	2
期刊	Journal of Labelled Compounds and Radiopharmaceuticals
卷	57
期	11
DOI	https://doi.org/10.1002/jlcr.3238
出版状态	已出版 - 29 9月 2014

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉

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10.1002/jlcr.3238

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引用此

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title = "Synthesis of [18O2]-curcumin",

abstract = "Curcumin, a pigment isolated from rhizomes of Curcuma longa, is a potent cancer chemopreventive and chemotherapeutic agent and is now evaluated in phase III human clinical trials. This report describes an efficient synthesis of [18O2]-curcumin. [18O2]-Curcumin was prepared in three steps from 1-iodo-2-methoxy-4-methylbenzene in an overall yield of 53\%.",

keywords = "Curcumin, Hydroxylation, O-labelling, Synthesis",

author = "Xiurui Shen and Xiaomei Yang and Ying Zhu and Xihuan Liu and Hongliang Wen",

note = "Publisher Copyright: Copyright {\textcopyright} 2014 John Wiley \& Sons, Ltd.",

year = "2014",

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day = "29",

doi = "10.1002/jlcr.3238",

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T1 - Synthesis of [18O2]-curcumin

AU - Shen, Xiurui

AU - Yang, Xiaomei

AU - Zhu, Ying

AU - Liu, Xihuan

AU - Wen, Hongliang

PY - 2014/9/29

Y1 - 2014/9/29

N2 - Curcumin, a pigment isolated from rhizomes of Curcuma longa, is a potent cancer chemopreventive and chemotherapeutic agent and is now evaluated in phase III human clinical trials. This report describes an efficient synthesis of [18O2]-curcumin. [18O2]-Curcumin was prepared in three steps from 1-iodo-2-methoxy-4-methylbenzene in an overall yield of 53%.

AB - Curcumin, a pigment isolated from rhizomes of Curcuma longa, is a potent cancer chemopreventive and chemotherapeutic agent and is now evaluated in phase III human clinical trials. This report describes an efficient synthesis of [18O2]-curcumin. [18O2]-Curcumin was prepared in three steps from 1-iodo-2-methoxy-4-methylbenzene in an overall yield of 53%.

KW - Curcumin

KW - Hydroxylation

KW - O-labelling

KW - Synthesis

UR - https://www.scopus.com/pages/publications/84915781784

U2 - 10.1002/jlcr.3238

DO - 10.1002/jlcr.3238

M3 - Article

C2 - 25267481

AN - SCOPUS:84915781784

SN - 0362-4803

VL - 57

SP - 658

EP - 659

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 11

ER -

Synthesis of [18O2]-curcumin

摘要

联合国可持续发展目标

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引用此

Synthesis of [¹⁸O₂]-curcumin