Synthesis of QS-21-based immunoadjuvants

Pengfei Wang; Qipu Dai; Punith Thogaripally; Ping Zhang; Suzanne M. Michalek

doi:10.1021/jo402118j

Synthesis of QS-21-based immunoadjuvants

Pengfei Wang^*, Qipu Dai, Punith Thogaripally, Ping Zhang, Suzanne M. Michalek

^*此作品的通讯作者

University of Alabama at Birmingham

科研成果: 期刊稿件 › 文章 › 同行评审

23 引用（Scopus）

摘要

Three structurally defined QS-21-based immune adjuvant candidates (2a-2c) have been synthesized. Application of the two-stage activation glycosylation approach utilizing allyl glycoside building blocks improved the synthetic accessibility of the new adjuvants. The efficient synthesis and establishment of the stand-alone adjuvanticity of the examined synthetic adjuvant (2b) open the door to the pursuit of a new series of structurally defined QS-saponin-based synthetic adjuvants.

源语言	英语
页（从-至）	11525-11534
页数	10
期刊	Journal of Organic Chemistry
卷	78
期	22
DOI	https://doi.org/10.1021/jo402118j
出版状态	已出版 - 15 11月 2013
已对外发布	是

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AU - Zhang, Ping

AU - Michalek, Suzanne M.

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Synthesis of QS-21-based immunoadjuvants

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