TY - JOUR
T1 - Synthesis of polysubstituted quinazolinones from the continuous reaction of α-Cyano disulfide ketene
AU - Liu, Xuan
AU - Shi, Daxin
AU - Tang, Jianhong
AU - Zhang, Qi
AU - Li, Jiarong
PY - 2011/10
Y1 - 2011/10
N2 - α-Cyano disulfide ketene 1, obtained from the reaction of α-methyl cyano-acetate, carbon disulfide and methyl iodide, condensated with acetophenone 2 to provide 3-cyano-2H-pyran-2-ketones 3, then ring transformation of 3 and malononitrile under base afforded aromatic o-amino dinitriles 4, and 4 reacted with ketone 5 to give the polysubstituted quinazolinone 6. This continuous reaction for the convenient synthesis of polysubstituted quinazolinone 6 has the follow advantages: simple raw materials, mild reaction condition, and simple operation.
AB - α-Cyano disulfide ketene 1, obtained from the reaction of α-methyl cyano-acetate, carbon disulfide and methyl iodide, condensated with acetophenone 2 to provide 3-cyano-2H-pyran-2-ketones 3, then ring transformation of 3 and malononitrile under base afforded aromatic o-amino dinitriles 4, and 4 reacted with ketone 5 to give the polysubstituted quinazolinone 6. This continuous reaction for the convenient synthesis of polysubstituted quinazolinone 6 has the follow advantages: simple raw materials, mild reaction condition, and simple operation.
KW - 2H-pyran-2-ketone-nitrile
KW - Aromatic o-amino dinitrile
KW - Continuous reaction
KW - Quinazolinone
KW - α-Cyano disulfide ketene
UR - https://www.scopus.com/pages/publications/84863070562
M3 - Article
AN - SCOPUS:84863070562
SN - 0253-2786
VL - 31
SP - 1710
EP - 1713
JO - Chinese Journal of Organic Chemistry
JF - Chinese Journal of Organic Chemistry
IS - 10
ER -