Synthesis and structure-activity relationship studies of quinoxaline derivatives as aldose reductase inhibitors

Bobin Wu; Yanchun Yang; Xiangyu Qin; Shuzhen Zhang; Chaojun Jing; Changjin Zhu; Bing Ma

doi:10.1002/cmdc.201300324

Synthesis and structure-activity relationship studies of quinoxaline derivatives as aldose reductase inhibitors

Bobin Wu
, Yanchun Yang
, Xiangyu Qin
, Shuzhen Zhang
, Chaojun Jing
, Changjin Zhu^*
, Bing Ma

^*此作品的通讯作者

化学与化工学院

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

83 引用（Scopus）

摘要

ARIs for diabetes: A series of 2-(3-benzyl-2-oxoquinoxalin-1(2H)-yl)acetic acid derivatives were designed and synthesized as inhibitors of aldose reductase (AR), a novel target for the treatment of diabetes complications. Most of the derivatives proved to be potent and selective, with IC₅₀ values in the low nanomolar to micromolar range.

源语言	英语
页（从-至）	1913-1917
页数	5
期刊	ChemMedChem
卷	8
期	12
DOI	https://doi.org/10.1002/cmdc.201300324
出版状态	已出版 - 12月 2013

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title = "Synthesis and structure-activity relationship studies of quinoxaline derivatives as aldose reductase inhibitors",

abstract = "ARIs for diabetes: A series of 2-(3-benzyl-2-oxoquinoxalin-1(2H)-yl)acetic acid derivatives were designed and synthesized as inhibitors of aldose reductase (AR), a novel target for the treatment of diabetes complications. Most of the derivatives proved to be potent and selective, with IC50 values in the low nanomolar to micromolar range.",

keywords = "aldehyde reductases, aldose reductases, diabetes complications, inhibitors, polyol pathway, quinoxalines, structure-activity relationships",

author = "Bobin Wu and Yanchun Yang and Xiangyu Qin and Shuzhen Zhang and Chaojun Jing and Changjin Zhu and Bing Ma",

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doi = "10.1002/cmdc.201300324",

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AU - Wu, Bobin

AU - Yang, Yanchun

AU - Qin, Xiangyu

AU - Zhang, Shuzhen

AU - Jing, Chaojun

AU - Zhu, Changjin

AU - Ma, Bing

PY - 2013/12

Y1 - 2013/12

N2 - ARIs for diabetes: A series of 2-(3-benzyl-2-oxoquinoxalin-1(2H)-yl)acetic acid derivatives were designed and synthesized as inhibitors of aldose reductase (AR), a novel target for the treatment of diabetes complications. Most of the derivatives proved to be potent and selective, with IC50 values in the low nanomolar to micromolar range.

AB - ARIs for diabetes: A series of 2-(3-benzyl-2-oxoquinoxalin-1(2H)-yl)acetic acid derivatives were designed and synthesized as inhibitors of aldose reductase (AR), a novel target for the treatment of diabetes complications. Most of the derivatives proved to be potent and selective, with IC50 values in the low nanomolar to micromolar range.

KW - aldehyde reductases

KW - aldose reductases

KW - diabetes complications

KW - inhibitors

KW - polyol pathway

KW - quinoxalines

KW - structure-activity relationships

UR - https://www.scopus.com/pages/publications/84889878958

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JO - ChemMedChem

JF - ChemMedChem

IS - 12

ER -

Synthesis and structure-activity relationship studies of quinoxaline derivatives as aldose reductase inhibitors

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