Synthesis and biological activity of titanocene carbohydrate

Zhan Zhu; Bing Nan Guo; Ya Li Wang; Jing Jing Dou; Shi Zhuo Xu

Synthesis and biological activity of titanocene carbohydrate

Zhan Zhu^*
, Bing Nan Guo
, Ya Li Wang
, Jing Jing Dou
, Shi Zhuo Xu

^*此作品的通讯作者

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

2 引用（Scopus）

摘要

Four new compounds of titanocene carbohydrate were synthesized by combining individual carbohydrate with Cp ₂TiCl ₂. They were C ₁₂H ₂₁O ₁₂· C ₁₀H ₁₀TiCl, C ₁₄H ₂₀NO ₁₁· C ₁₀H ₁₀TiCl·8H ₂O, C ₁₂H ₂₁O ₁₂· C ₁₄H ₂₀NO ₁₁· C ₁₀H ₁₀Ti·26H ₂O and C ₁₄H ₂₄NO ₁₃ C ₁₀H ₁₀TiCl. All compounds were characterizated by IR, ¹H-NMR spectroscopy and elemental analysis and were tested to examine the growth of uterine cancer cells. Biological experiments show that all presented compounds are dissolved easily in water and have better anti-tumor effects. In addition, the target affectation to liver of glycanonic acid is exhibited.

源语言	英语
页（从-至）	531-534
页数	4
期刊	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
卷	32
期	5
出版状态	已出版 - 5月 2012
已对外发布	是

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉

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引用此

@article{4067bab105e949039cb1f0b31260e5db,

title = "Synthesis and biological activity of titanocene carbohydrate",

abstract = "Four new compounds of titanocene carbohydrate were synthesized by combining individual carbohydrate with Cp 2TiCl 2. They were C 12H 21O 12· C 10H 10TiCl, C 14H 20NO 11· C 10H 10TiCl·8H 2O, C 12H 21O 12· C 14H 20NO 11· C 10H 10Ti·26H 2O and C 14H 24NO 13 C 10H 10TiCl. All compounds were characterizated by IR, 1H-NMR spectroscopy and elemental analysis and were tested to examine the growth of uterine cancer cells. Biological experiments show that all presented compounds are dissolved easily in water and have better anti-tumor effects. In addition, the target affectation to liver of glycanonic acid is exhibited.",

keywords = "Cervical cancer, Hepatic targeting, Liver cancer, Titanocene carbohydrate, Titanocene dichloride",

author = "Zhan Zhu and Guo, \{Bing Nan\} and Wang, \{Ya Li\} and Dou, \{Jing Jing\} and Xu, \{Shi Zhuo\}",

year = "2012",

month = may,

language = "English",

volume = "32",

pages = "531--534",

journal = "Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology",

issn = "1001-0645",

publisher = "Beijing Institute of Technology",

number = "5",

}

TY - JOUR

T1 - Synthesis and biological activity of titanocene carbohydrate

AU - Zhu, Zhan

AU - Guo, Bing Nan

AU - Wang, Ya Li

AU - Dou, Jing Jing

AU - Xu, Shi Zhuo

PY - 2012/5

Y1 - 2012/5

N2 - Four new compounds of titanocene carbohydrate were synthesized by combining individual carbohydrate with Cp 2TiCl 2. They were C 12H 21O 12· C 10H 10TiCl, C 14H 20NO 11· C 10H 10TiCl·8H 2O, C 12H 21O 12· C 14H 20NO 11· C 10H 10Ti·26H 2O and C 14H 24NO 13 C 10H 10TiCl. All compounds were characterizated by IR, 1H-NMR spectroscopy and elemental analysis and were tested to examine the growth of uterine cancer cells. Biological experiments show that all presented compounds are dissolved easily in water and have better anti-tumor effects. In addition, the target affectation to liver of glycanonic acid is exhibited.

AB - Four new compounds of titanocene carbohydrate were synthesized by combining individual carbohydrate with Cp 2TiCl 2. They were C 12H 21O 12· C 10H 10TiCl, C 14H 20NO 11· C 10H 10TiCl·8H 2O, C 12H 21O 12· C 14H 20NO 11· C 10H 10Ti·26H 2O and C 14H 24NO 13 C 10H 10TiCl. All compounds were characterizated by IR, 1H-NMR spectroscopy and elemental analysis and were tested to examine the growth of uterine cancer cells. Biological experiments show that all presented compounds are dissolved easily in water and have better anti-tumor effects. In addition, the target affectation to liver of glycanonic acid is exhibited.

KW - Cervical cancer

KW - Hepatic targeting

KW - Liver cancer

KW - Titanocene carbohydrate

KW - Titanocene dichloride

UR - https://www.scopus.com/pages/publications/84863748885

M3 - Article

AN - SCOPUS:84863748885

SN - 1001-0645

VL - 32

SP - 531

EP - 534

JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

IS - 5

ER -

Synthesis and biological activity of titanocene carbohydrate

摘要

联合国可持续发展目标

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