Synthesis and antitumor activity of novel 2′,3′-dideoxy-2′,3′-diethanethionucleosides bearing 1,2,3-triazole residues

Jin Lan Yu; Qin Pei Wu; Qing Shan Zhang; Yan Hong Liu; Yun Zheng Li; Zi Ming Zhou

doi:10.1016/j.bmcl.2009.10.127

Synthesis and antitumor activity of novel 2′,3′-dideoxy-2′,3′-diethanethionucleosides bearing 1,2,3-triazole residues

Jin Lan Yu
, Qin Pei Wu^*
, Qing Shan Zhang
, Yan Hong Liu
, Yun Zheng Li
, Zi Ming Zhou

^*此作品的通讯作者

化学与化工学院

Beijing Institute of Technology
CAS - Technical Institute of Physics and Chemistry

科研成果: 期刊稿件 › 文章 › 同行评审

77 引用（Scopus）

摘要

A series of novel 2′,3′-dideoxy-2′,3′-diethanethioribonucleosides and those modified with a triazole ring were prepared in excellent yields and their antitumor activity was evaluated. Nucleosides with a triazole ring, 16a-16c, showed significantly improved activity towards a broad range of tumor cell lines.

源语言	英语
页（从-至）	240-243
页数	4
期刊	Bioorganic and Medicinal Chemistry Letters
卷	20
期	1
DOI	https://doi.org/10.1016/j.bmcl.2009.10.127
出版状态	已出版 - 1 1月 2010

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10.1016/j.bmcl.2009.10.127

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title = "Synthesis and antitumor activity of novel 2′,3′-dideoxy-2′,3′-diethanethionucleosides bearing 1,2,3-triazole residues",

abstract = "A series of novel 2′,3′-dideoxy-2′,3′-diethanethioribonucleosides and those modified with a triazole ring were prepared in excellent yields and their antitumor activity was evaluated. Nucleosides with a triazole ring, 16a-16c, showed significantly improved activity towards a broad range of tumor cell lines.",

keywords = "Antitumor, Nucleoside, Thiol, Triazole",

author = "Yu, \{Jin Lan\} and Wu, \{Qin Pei\} and Zhang, \{Qing Shan\} and Liu, \{Yan Hong\} and Li, \{Yun Zheng\} and Zhou, \{Zi Ming\}",

year = "2010",

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doi = "10.1016/j.bmcl.2009.10.127",

language = "English",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Synthesis and antitumor activity of novel 2′,3′-dideoxy-2′,3′-diethanethionucleosides bearing 1,2,3-triazole residues

AU - Yu, Jin Lan

AU - Wu, Qin Pei

AU - Zhang, Qing Shan

AU - Liu, Yan Hong

AU - Li, Yun Zheng

AU - Zhou, Zi Ming

PY - 2010/1/1

Y1 - 2010/1/1

N2 - A series of novel 2′,3′-dideoxy-2′,3′-diethanethioribonucleosides and those modified with a triazole ring were prepared in excellent yields and their antitumor activity was evaluated. Nucleosides with a triazole ring, 16a-16c, showed significantly improved activity towards a broad range of tumor cell lines.

AB - A series of novel 2′,3′-dideoxy-2′,3′-diethanethioribonucleosides and those modified with a triazole ring were prepared in excellent yields and their antitumor activity was evaluated. Nucleosides with a triazole ring, 16a-16c, showed significantly improved activity towards a broad range of tumor cell lines.

KW - Antitumor

KW - Nucleoside

KW - Thiol

KW - Triazole

UR - https://www.scopus.com/pages/publications/72049093453

U2 - 10.1016/j.bmcl.2009.10.127

DO - 10.1016/j.bmcl.2009.10.127

M3 - Article

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AN - SCOPUS:72049093453

SN - 0960-894X

VL - 20

SP - 240

EP - 243

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

Synthesis and antitumor activity of novel 2′,3′-dideoxy-2′,3′-diethanethionucleosides bearing 1,2,3-triazole residues

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