Squaramide-tertiary amine catalyzed asymmetric cascade sulfa-Michael/ Michael addition via dynamic kinetic resolution: Access to highly functionalized chromans with three contiguous stereocenters

Wen Yang; Yi Yang; Da Ming Du

doi:10.1021/ol400025a

Squaramide-tertiary amine catalyzed asymmetric cascade sulfa-Michael/ Michael addition via dynamic kinetic resolution: Access to highly functionalized chromans with three contiguous stereocenters

Wen Yang
, Yi Yang
, Da Ming Du^*

^*此作品的通讯作者

化学与化工学院

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

93 引用（Scopus）

摘要

An efficient asymmetric cascade sulfa-Michael/Michael addition reaction catalyzed by a chiral bifunctional squaramide-tertiary amine catalyst has been developed. This organocatalytic cascade reaction provides easy access to highly functionalized chromans with three contiguous stereocenters, including one quaternary center. In addition, a novel cascade sulfa Michael/retro-sulfa- Michael/sulfa-Michael/Michael reaction process, involving dynamic kinetic resolution, is described.

源语言	英语
页（从-至）	1190-1193
页数	4
期刊	Organic Letters
卷	15
期	6
DOI	https://doi.org/10.1021/ol400025a
出版状态	已出版 - 15 3月 2013

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title = "Squaramide-tertiary amine catalyzed asymmetric cascade sulfa-Michael/ Michael addition via dynamic kinetic resolution: Access to highly functionalized chromans with three contiguous stereocenters",

abstract = "An efficient asymmetric cascade sulfa-Michael/Michael addition reaction catalyzed by a chiral bifunctional squaramide-tertiary amine catalyst has been developed. This organocatalytic cascade reaction provides easy access to highly functionalized chromans with three contiguous stereocenters, including one quaternary center. In addition, a novel cascade sulfa Michael/retro-sulfa- Michael/sulfa-Michael/Michael reaction process, involving dynamic kinetic resolution, is described.",

author = "Wen Yang and Yi Yang and Du, \{Da Ming\}",

year = "2013",

month = mar,

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doi = "10.1021/ol400025a",

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pages = "1190--1193",

journal = "Organic Letters",

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T1 - Squaramide-tertiary amine catalyzed asymmetric cascade sulfa-Michael/ Michael addition via dynamic kinetic resolution

T2 - Access to highly functionalized chromans with three contiguous stereocenters

AU - Yang, Wen

AU - Yang, Yi

AU - Du, Da Ming

PY - 2013/3/15

Y1 - 2013/3/15

N2 - An efficient asymmetric cascade sulfa-Michael/Michael addition reaction catalyzed by a chiral bifunctional squaramide-tertiary amine catalyst has been developed. This organocatalytic cascade reaction provides easy access to highly functionalized chromans with three contiguous stereocenters, including one quaternary center. In addition, a novel cascade sulfa Michael/retro-sulfa- Michael/sulfa-Michael/Michael reaction process, involving dynamic kinetic resolution, is described.

AB - An efficient asymmetric cascade sulfa-Michael/Michael addition reaction catalyzed by a chiral bifunctional squaramide-tertiary amine catalyst has been developed. This organocatalytic cascade reaction provides easy access to highly functionalized chromans with three contiguous stereocenters, including one quaternary center. In addition, a novel cascade sulfa Michael/retro-sulfa- Michael/sulfa-Michael/Michael reaction process, involving dynamic kinetic resolution, is described.

UR - https://www.scopus.com/pages/publications/84875207089

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DO - 10.1021/ol400025a

M3 - Article

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AN - SCOPUS:84875207089

SN - 1523-7060

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JF - Organic Letters

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ER -

Squaramide-tertiary amine catalyzed asymmetric cascade sulfa-Michael/ Michael addition via dynamic kinetic resolution: Access to highly functionalized chromans with three contiguous stereocenters

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