Singlet Oxygen Luminescence Image in Blood Vessels During Vascular-Targeted Photodynamic Therapy

Lisheng Lin; Huiyun Lin; Yi Shen; Defu Chen; Ying Gu; Brian C. Wilson; Buhong Li

doi:10.1111/php.13264

Singlet Oxygen Luminescence Image in Blood Vessels During Vascular-Targeted Photodynamic Therapy

Lisheng Lin
, Huiyun Lin
, Yi Shen
, Defu Chen
, Ying Gu
, Brian C. Wilson
, Buhong Li^*

^*此作品的通讯作者

Fujian Normal University
General Hospital of People's Liberation Army
University of Toronto

科研成果: 期刊稿件 › 文章 › 同行评审

19 引用（Scopus）

摘要

Singlet oxygen (¹O₂) is widely regarded as the main cytotoxic substance that induces the biological damage for photodynamic therapy (PDT). In this study, the previously developed near-infrared (NIR) optical imaging system was optimized for fast imaging of ¹O₂ luminescence. The optical imaging system enables direct imaging of ¹O₂ luminescence in blood vessels within 2 s during vascular-targeted PDT (V-PDT), which makes this system extremely practical for in vivo studies. The dependence of RB concentration on ¹O₂ luminescence image was investigated for V-PDT, and the data imply that 1270 nm signal is attributed to ¹O₂ luminescence. The imaging system operates with a field of view of 9.60 × 7.68 mm² and a spatial resolution of 30 μm, which holds the potential to elucidate the correlation between cumulative ¹O₂ luminescence and vasoconstriction for V-PDT.

源语言	英语
页（从-至）	646-651
页数	6
期刊	Photochemistry and Photobiology
卷	96
期	3
DOI	https://doi.org/10.1111/php.13264
出版状态	已出版 - 1 5月 2020
已对外发布	是

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title = "Singlet Oxygen Luminescence Image in Blood Vessels During Vascular-Targeted Photodynamic Therapy",

abstract = "Singlet oxygen (1O2) is widely regarded as the main cytotoxic substance that induces the biological damage for photodynamic therapy (PDT). In this study, the previously developed near-infrared (NIR) optical imaging system was optimized for fast imaging of 1O2 luminescence. The optical imaging system enables direct imaging of 1O2 luminescence in blood vessels within 2 s during vascular-targeted PDT (V-PDT), which makes this system extremely practical for in vivo studies. The dependence of RB concentration on 1O2 luminescence image was investigated for V-PDT, and the data imply that 1270 nm signal is attributed to 1O2 luminescence. The imaging system operates with a field of view of 9.60 {\texttimes} 7.68 mm2 and a spatial resolution of 30 μm, which holds the potential to elucidate the correlation between cumulative 1O2 luminescence and vasoconstriction for V-PDT.",

author = "Lisheng Lin and Huiyun Lin and Yi Shen and Defu Chen and Ying Gu and Wilson, \{Brian C.\} and Buhong Li",

note = "Publisher Copyright: {\textcopyright} 2020 American Society for Photobiology",

year = "2020",

month = may,

day = "1",

doi = "10.1111/php.13264",

language = "English",

volume = "96",

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TY - JOUR

T1 - Singlet Oxygen Luminescence Image in Blood Vessels During Vascular-Targeted Photodynamic Therapy

AU - Lin, Lisheng

AU - Lin, Huiyun

AU - Shen, Yi

AU - Chen, Defu

AU - Gu, Ying

AU - Wilson, Brian C.

AU - Li, Buhong

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Singlet oxygen (1O2) is widely regarded as the main cytotoxic substance that induces the biological damage for photodynamic therapy (PDT). In this study, the previously developed near-infrared (NIR) optical imaging system was optimized for fast imaging of 1O2 luminescence. The optical imaging system enables direct imaging of 1O2 luminescence in blood vessels within 2 s during vascular-targeted PDT (V-PDT), which makes this system extremely practical for in vivo studies. The dependence of RB concentration on 1O2 luminescence image was investigated for V-PDT, and the data imply that 1270 nm signal is attributed to 1O2 luminescence. The imaging system operates with a field of view of 9.60 × 7.68 mm2 and a spatial resolution of 30 μm, which holds the potential to elucidate the correlation between cumulative 1O2 luminescence and vasoconstriction for V-PDT.

AB - Singlet oxygen (1O2) is widely regarded as the main cytotoxic substance that induces the biological damage for photodynamic therapy (PDT). In this study, the previously developed near-infrared (NIR) optical imaging system was optimized for fast imaging of 1O2 luminescence. The optical imaging system enables direct imaging of 1O2 luminescence in blood vessels within 2 s during vascular-targeted PDT (V-PDT), which makes this system extremely practical for in vivo studies. The dependence of RB concentration on 1O2 luminescence image was investigated for V-PDT, and the data imply that 1270 nm signal is attributed to 1O2 luminescence. The imaging system operates with a field of view of 9.60 × 7.68 mm2 and a spatial resolution of 30 μm, which holds the potential to elucidate the correlation between cumulative 1O2 luminescence and vasoconstriction for V-PDT.

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DO - 10.1111/php.13264

M3 - Article

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SN - 0031-8655

VL - 96

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JO - Photochemistry and Photobiology

JF - Photochemistry and Photobiology

IS - 3

ER -

Singlet Oxygen Luminescence Image in Blood Vessels During Vascular-Targeted Photodynamic Therapy

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