Ruthenium-catalyzed remote C5-sulfonation of: N -alkyl-8-aminoquinolines

Xuri Liu; Han Zhang; Fanzhi Yang; Bo Wang

doi:10.1039/c9ob01357a

Ruthenium-catalyzed remote C5-sulfonation of: N -alkyl-8-aminoquinolines

Xuri Liu
, Han Zhang
, Fanzhi Yang^*
, Bo Wang

^*此作品的通讯作者

化学与化工学院

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

14 引用（Scopus）

摘要

There is an increasing demand for the methodologies of positionally selective remote C-H functionalizations. We herein report the ruthenium-catalyzed remote C5-selective sulfonation of 8-aminoquinoline derivatives. Moderate to high yields were obtained with different substituted substrates. The catalytic system exhibited a high regio-selectivity, as well as good functional group tolerance. Mechanistic study supported a radical pathway. A bifunctional ruthenium-catalytic cycle is proposed.

源语言	英语
页（从-至）	7564-7568
页数	5
期刊	Organic and Biomolecular Chemistry
卷	17
期	32
DOI	https://doi.org/10.1039/c9ob01357a
出版状态	已出版 - 2019

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abstract = "There is an increasing demand for the methodologies of positionally selective remote C-H functionalizations. We herein report the ruthenium-catalyzed remote C5-selective sulfonation of 8-aminoquinoline derivatives. Moderate to high yields were obtained with different substituted substrates. The catalytic system exhibited a high regio-selectivity, as well as good functional group tolerance. Mechanistic study supported a radical pathway. A bifunctional ruthenium-catalytic cycle is proposed.",

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AU - Zhang, Han

AU - Yang, Fanzhi

AU - Wang, Bo

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N2 - There is an increasing demand for the methodologies of positionally selective remote C-H functionalizations. We herein report the ruthenium-catalyzed remote C5-selective sulfonation of 8-aminoquinoline derivatives. Moderate to high yields were obtained with different substituted substrates. The catalytic system exhibited a high regio-selectivity, as well as good functional group tolerance. Mechanistic study supported a radical pathway. A bifunctional ruthenium-catalytic cycle is proposed.

AB - There is an increasing demand for the methodologies of positionally selective remote C-H functionalizations. We herein report the ruthenium-catalyzed remote C5-selective sulfonation of 8-aminoquinoline derivatives. Moderate to high yields were obtained with different substituted substrates. The catalytic system exhibited a high regio-selectivity, as well as good functional group tolerance. Mechanistic study supported a radical pathway. A bifunctional ruthenium-catalytic cycle is proposed.

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DO - 10.1039/c9ob01357a

M3 - Article

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ER -

Ruthenium-catalyzed remote C5-sulfonation of: N -alkyl-8-aminoquinolines

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