Rh-Catalyzed Hydroheteroarylation of Styrenes: Access to Alkylated Heteroarenes with All-Carbon Quaternary Centers

Zhen Wang; Yi Xin Wang; Xiao Hui Yang

doi:10.1002/ejoc.202300428

Rh-Catalyzed Hydroheteroarylation of Styrenes: Access to Alkylated Heteroarenes with All-Carbon Quaternary Centers

Zhen Wang
, Yi Xin Wang
, Xiao Hui Yang^*

^*此作品的通讯作者

Beijing Institute of Technology
Nankai University

科研成果: 期刊稿件 › 文章 › 同行评审

1 引用（Scopus）

摘要

Heteroarenes are common moieties in pharmaceuticals and naturally bioactive compounds. In this work, an efficient and atom-economic rhodium and thiophenol co-catalyzed hydroheteroarylation of styrenes with heteroarenes is reported. Alkylated unprotected heteroarenes are accessed under low catalyst loading. This protocol provides straightforward access to indoles bearing an all-carbon quaternary center at the C3-position.

源语言	英语
期刊论文编号	e202300428
期刊	European Journal of Organic Chemistry
卷	26
期	34
DOI	https://doi.org/10.1002/ejoc.202300428
出版状态	已出版 - 6 9月 2023
已对外发布	是

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10.1002/ejoc.202300428

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title = "Rh-Catalyzed Hydroheteroarylation of Styrenes: Access to Alkylated Heteroarenes with All-Carbon Quaternary Centers",

abstract = "Heteroarenes are common moieties in pharmaceuticals and naturally bioactive compounds. In this work, an efficient and atom-economic rhodium and thiophenol co-catalyzed hydroheteroarylation of styrenes with heteroarenes is reported. Alkylated unprotected heteroarenes are accessed under low catalyst loading. This protocol provides straightforward access to indoles bearing an all-carbon quaternary center at the C3-position.",

keywords = "heteroarenes, hydroheteroarylation, indoles, rhodium, styrenes",

author = "Zhen Wang and Wang, \{Yi Xin\} and Yang, \{Xiao Hui\}",

note = "Publisher Copyright: {\textcopyright} 2023 Wiley-VCH GmbH.",

year = "2023",

month = sep,

day = "6",

doi = "10.1002/ejoc.202300428",

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volume = "26",

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T1 - Rh-Catalyzed Hydroheteroarylation of Styrenes

T2 - Access to Alkylated Heteroarenes with All-Carbon Quaternary Centers

AU - Wang, Zhen

AU - Wang, Yi Xin

AU - Yang, Xiao Hui

PY - 2023/9/6

Y1 - 2023/9/6

N2 - Heteroarenes are common moieties in pharmaceuticals and naturally bioactive compounds. In this work, an efficient and atom-economic rhodium and thiophenol co-catalyzed hydroheteroarylation of styrenes with heteroarenes is reported. Alkylated unprotected heteroarenes are accessed under low catalyst loading. This protocol provides straightforward access to indoles bearing an all-carbon quaternary center at the C3-position.

AB - Heteroarenes are common moieties in pharmaceuticals and naturally bioactive compounds. In this work, an efficient and atom-economic rhodium and thiophenol co-catalyzed hydroheteroarylation of styrenes with heteroarenes is reported. Alkylated unprotected heteroarenes are accessed under low catalyst loading. This protocol provides straightforward access to indoles bearing an all-carbon quaternary center at the C3-position.

KW - heteroarenes

KW - hydroheteroarylation

KW - indoles

KW - rhodium

KW - styrenes

UR - https://www.scopus.com/pages/publications/85164834222

U2 - 10.1002/ejoc.202300428

DO - 10.1002/ejoc.202300428

M3 - Article

AN - SCOPUS:85164834222

SN - 1434-193X

VL - 26

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 34

M1 - e202300428

ER -

Rh-Catalyzed Hydroheteroarylation of Styrenes: Access to Alkylated Heteroarenes with All-Carbon Quaternary Centers

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