Reaction-free mitochondrial membrane potential independent luminogens with aggregation-induced emission characteristics for live neuron imaging

Hojeong Park; Guangle Niu; Alex Y.H. Wong; Eric Y. Yu; Ryan T.K. Kwok; Ben Zhong Tang

doi:10.1039/d4cc06022a

Reaction-free mitochondrial membrane potential independent luminogens with aggregation-induced emission characteristics for live neuron imaging

Hojeong Park
, Guangle Niu
, Alex Y.H. Wong
, Eric Y. Yu
, Ryan T.K. Kwok
, Ben Zhong Tang^*

^*此作品的通讯作者

化学与化工学院

Hong Kong University of Science and Technology
Karolinska Institutet
The Chinese University of Hong Kong, Shenzhen

科研成果: 期刊稿件 › 文章 › 同行评审

1 引用（Scopus）

摘要

We developed novel photostable mitochondria targeting probes based on aggregation-induced emission (AIE) luminogens with a cyanostilbene core. The introduction of an alkyl chain onto the pyridinium moiety enhanced their interaction with the mitochondrial membrane. This design effectively prevents probe leakage following mitochondrial membrane depolarization while significantly reducing cytotoxicity.

源语言	英语
页（从-至）	3536-3539
页数	4
期刊	Chemical Communications
卷	61
期	17
DOI	https://doi.org/10.1039/d4cc06022a
出版状态	已出版 - 30 1月 2025

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10.1039/d4cc06022a

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title = "Reaction-free mitochondrial membrane potential independent luminogens with aggregation-induced emission characteristics for live neuron imaging",

abstract = "We developed novel photostable mitochondria targeting probes based on aggregation-induced emission (AIE) luminogens with a cyanostilbene core. The introduction of an alkyl chain onto the pyridinium moiety enhanced their interaction with the mitochondrial membrane. This design effectively prevents probe leakage following mitochondrial membrane depolarization while significantly reducing cytotoxicity.",

author = "Hojeong Park and Guangle Niu and Wong, \{Alex Y.H.\} and Yu, \{Eric Y.\} and Kwok, \{Ryan T.K.\} and Tang, \{Ben Zhong\}",

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AU - Park, Hojeong

AU - Niu, Guangle

AU - Wong, Alex Y.H.

AU - Yu, Eric Y.

AU - Kwok, Ryan T.K.

AU - Tang, Ben Zhong

PY - 2025/1/30

Y1 - 2025/1/30

N2 - We developed novel photostable mitochondria targeting probes based on aggregation-induced emission (AIE) luminogens with a cyanostilbene core. The introduction of an alkyl chain onto the pyridinium moiety enhanced their interaction with the mitochondrial membrane. This design effectively prevents probe leakage following mitochondrial membrane depolarization while significantly reducing cytotoxicity.

AB - We developed novel photostable mitochondria targeting probes based on aggregation-induced emission (AIE) luminogens with a cyanostilbene core. The introduction of an alkyl chain onto the pyridinium moiety enhanced their interaction with the mitochondrial membrane. This design effectively prevents probe leakage following mitochondrial membrane depolarization while significantly reducing cytotoxicity.

UR - https://www.scopus.com/pages/publications/85217523069

U2 - 10.1039/d4cc06022a

DO - 10.1039/d4cc06022a

M3 - Article

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EP - 3539

JO - Chemical Communications

JF - Chemical Communications

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ER -

Reaction-free mitochondrial membrane potential independent luminogens with aggregation-induced emission characteristics for live neuron imaging

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