TY - JOUR
T1 - Psychoactive substances
T2 - novel molecular insights and therapeutic potential for Alzheimer's disease
AU - Fu, Chonglei
AU - Li, Xuehui
AU - Liu, Xiaoxing
AU - Zheng, Yongbo
AU - Ma, Xiangxian
AU - Zhang, Bo
AU - Chen, Si
AU - Hu, Lingming
AU - Su, Sizhen
AU - Wang, Xiaokun
AU - Sun, Jie
AU - Yin, Qingqing
AU - Wang, Yumei
AU - Fu, Xiaolong
AU - Bao, Yanping
AU - Xue, Yanxue
AU - Xin, Tao
AU - Lu, Lin
AU - Zou, Guichang
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/12
Y1 - 2025/12
N2 - Alzheimer's disease (AD) is a major neurodegenerative disorder that causes severe cognitive decline and poses a significant burden on global health systems. Despite extensive research, effective treatments to stop neurodegeneration or promote neuronal regeneration in AD remain elusive. Psychoactive substances as modulators of neurophysiological functions, have received increased attention in research. The main psychoactive agents, such as central nervous system depressants and stimulants, cannabinoids, psychedelics, opioids and ketamine, are being explored for their abilities to enhance learning and cognitive performance and potential neurorestorative functions. In this paper, we review the molecular mechanisms and therapeutic potential of psychoactive substances in AD, in the aim to guide future research directions.
AB - Alzheimer's disease (AD) is a major neurodegenerative disorder that causes severe cognitive decline and poses a significant burden on global health systems. Despite extensive research, effective treatments to stop neurodegeneration or promote neuronal regeneration in AD remain elusive. Psychoactive substances as modulators of neurophysiological functions, have received increased attention in research. The main psychoactive agents, such as central nervous system depressants and stimulants, cannabinoids, psychedelics, opioids and ketamine, are being explored for their abilities to enhance learning and cognitive performance and potential neurorestorative functions. In this paper, we review the molecular mechanisms and therapeutic potential of psychoactive substances in AD, in the aim to guide future research directions.
KW - Alzheimer's disease
KW - Challenges
KW - Molecular insights
KW - Psychoactive substances
KW - Therapeutic potential
UR - https://www.scopus.com/pages/publications/105011695369
U2 - 10.1186/s40035-025-00498-1
DO - 10.1186/s40035-025-00498-1
M3 - Review article
AN - SCOPUS:105011695369
SN - 2047-9158
VL - 14
JO - Translational Neurodegeneration
JF - Translational Neurodegeneration
IS - 1
M1 - 38
ER -