Preparation of highly purified nafronyl oxalate and Its X-ray single crystal structure

Min Xue; Jin Liang Wang; Wei Fa Yu; Dao Lin Wang; Jun Zhang; Zhi Ming Zhou

Preparation of highly purified nafronyl oxalate and Its X-ray single crystal structure

Min Xue^*
, Jin Liang Wang
, Wei Fa Yu
, Dao Lin Wang
, Jun Zhang
, Zhi Ming Zhou

^*此作品的通讯作者

化学与化工学院

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

摘要

Several different technological processes, including that of high vacuum fractionation, column chromatography and recrystallization, have been tried to reduce the quantity of impurities contained in the raw nafronyl oxalate. HPLC analysis showed that a combination of high vacuum distillation and water recrystallization led to a high quality product (99. 6% purity), meeting the British Pharmocoepia (1998) standard. X-ray single crystal analysis confirmed the structure of the title compound as first reported.

源语言	英语
页（从-至）	658-661
页数	4
期刊	He Jishu/Nuclear Techniques
卷	22
期	5
出版状态	已出版 - 1999

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title = "Preparation of highly purified nafronyl oxalate and Its X-ray single crystal structure",

abstract = "Several different technological processes, including that of high vacuum fractionation, column chromatography and recrystallization, have been tried to reduce the quantity of impurities contained in the raw nafronyl oxalate. HPLC analysis showed that a combination of high vacuum distillation and water recrystallization led to a high quality product (99. 6\% purity), meeting the British Pharmocoepia (1998) standard. X-ray single crystal analysis confirmed the structure of the title compound as first reported.",

keywords = "Column chromatography, HPLC, High vacuum distillation, Impurity, Nafronyl oxalate, Single crystal structure",

author = "Min Xue and Wang, \{Jin Liang\} and Yu, \{Wei Fa\} and Wang, \{Dao Lin\} and Jun Zhang and Zhou, \{Zhi Ming\}",

year = "1999",

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journal = "He Jishu/Nuclear Techniques",

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T1 - Preparation of highly purified nafronyl oxalate and Its X-ray single crystal structure

AU - Xue, Min

AU - Wang, Jin Liang

AU - Yu, Wei Fa

AU - Wang, Dao Lin

AU - Zhang, Jun

AU - Zhou, Zhi Ming

PY - 1999

Y1 - 1999

N2 - Several different technological processes, including that of high vacuum fractionation, column chromatography and recrystallization, have been tried to reduce the quantity of impurities contained in the raw nafronyl oxalate. HPLC analysis showed that a combination of high vacuum distillation and water recrystallization led to a high quality product (99. 6% purity), meeting the British Pharmocoepia (1998) standard. X-ray single crystal analysis confirmed the structure of the title compound as first reported.

AB - Several different technological processes, including that of high vacuum fractionation, column chromatography and recrystallization, have been tried to reduce the quantity of impurities contained in the raw nafronyl oxalate. HPLC analysis showed that a combination of high vacuum distillation and water recrystallization led to a high quality product (99. 6% purity), meeting the British Pharmocoepia (1998) standard. X-ray single crystal analysis confirmed the structure of the title compound as first reported.

KW - Column chromatography

KW - HPLC

KW - High vacuum distillation

KW - Impurity

KW - Nafronyl oxalate

KW - Single crystal structure

UR - https://www.scopus.com/pages/publications/73549123625

M3 - Article

AN - SCOPUS:73549123625

SN - 0253-3219

VL - 22

SP - 658

EP - 661

JO - He Jishu/Nuclear Techniques

JF - He Jishu/Nuclear Techniques

IS - 5

ER -

Preparation of highly purified nafronyl oxalate and Its X-ray single crystal structure

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