Phosphine-mediated formal [5 + 1] aminobenzannulations of Morita-Baylis-Hillman carbonates with isocyanates

Wei Cai; Yanxin Hu; Nan Wang; You Huang

doi:10.1039/d4qo01651c

Phosphine-mediated formal [5 + 1] aminobenzannulations of Morita-Baylis-Hillman carbonates with isocyanates

Wei Cai
, Yanxin Hu
, Nan Wang
, You Huang^*

^*此作品的通讯作者

Nankai University

科研成果: 期刊稿件 › 文章 › 同行评审

5 引用（Scopus）

摘要

Morita-Baylis-Hillman (MBH) carbonates have been widely used in many meaningful annulations. Herein we report the use of an MBH-carbonate-derived relatively long-chained, C5, synthon to enable a formal [5 + 1] annulation with readily available isocyanates. The reaction proceeds via a tandem Wittig and aminobenzannulation process, smoothly constructing both diarylamines and anilines with a broad scope of substrates and excellent chemoselectively.

源语言	英语
页（从-至）	7130-7135
页数	6
期刊	Organic Chemistry Frontiers
卷	11
期	24
DOI	https://doi.org/10.1039/d4qo01651c
出版状态	已出版 - 11 10月 2024
已对外发布	是

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abstract = "Morita-Baylis-Hillman (MBH) carbonates have been widely used in many meaningful annulations. Herein we report the use of an MBH-carbonate-derived relatively long-chained, C5, synthon to enable a formal [5 + 1] annulation with readily available isocyanates. The reaction proceeds via a tandem Wittig and aminobenzannulation process, smoothly constructing both diarylamines and anilines with a broad scope of substrates and excellent chemoselectively.",

author = "Wei Cai and Yanxin Hu and Nan Wang and You Huang",

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T1 - Phosphine-mediated formal [5 + 1] aminobenzannulations of Morita-Baylis-Hillman carbonates with isocyanates

AU - Cai, Wei

AU - Hu, Yanxin

AU - Wang, Nan

AU - Huang, You

PY - 2024/10/11

Y1 - 2024/10/11

N2 - Morita-Baylis-Hillman (MBH) carbonates have been widely used in many meaningful annulations. Herein we report the use of an MBH-carbonate-derived relatively long-chained, C5, synthon to enable a formal [5 + 1] annulation with readily available isocyanates. The reaction proceeds via a tandem Wittig and aminobenzannulation process, smoothly constructing both diarylamines and anilines with a broad scope of substrates and excellent chemoselectively.

AB - Morita-Baylis-Hillman (MBH) carbonates have been widely used in many meaningful annulations. Herein we report the use of an MBH-carbonate-derived relatively long-chained, C5, synthon to enable a formal [5 + 1] annulation with readily available isocyanates. The reaction proceeds via a tandem Wittig and aminobenzannulation process, smoothly constructing both diarylamines and anilines with a broad scope of substrates and excellent chemoselectively.

UR - https://www.scopus.com/pages/publications/85207398820

U2 - 10.1039/d4qo01651c

DO - 10.1039/d4qo01651c

M3 - Article

AN - SCOPUS:85207398820

SN - 2052-4110

VL - 11

SP - 7130

EP - 7135

JO - Organic Chemistry Frontiers

JF - Organic Chemistry Frontiers

IS - 24

ER -

Phosphine-mediated formal [5 + 1] aminobenzannulations of Morita-Baylis-Hillman carbonates with isocyanates

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