Optimized fluorodendrimer-incorporated hybrid lipid-polymer nanoparticles for efficient siRNA delivery

Qingqing Xiong; Yujing Li; Kun Zhou; Ping Chen; Hua Guo; Lu Chen; Jianxun Ding; Tianqiang Song; Jinjun Shi

doi:10.1039/c9bm01738k

Optimized fluorodendrimer-incorporated hybrid lipid-polymer nanoparticles for efficient siRNA delivery

Qingqing Xiong
, Yujing Li
, Kun Zhou
, Ping Chen
, Hua Guo
, Lu Chen
, Jianxun Ding
, Tianqiang Song
, Jinjun Shi

Tianjin Medical University
Harvard University
CAS - Changchun Institute of Applied Chemistry

科研成果: 期刊稿件 › 文章 › 同行评审

22 引用（Scopus）

摘要

Six cationic lipidoid fluorodendrimers are synthesized to construct hybrid lipid-polymer nanoparticles for siRNA delivery. By screening the nanoplatforms including fluorodendrimers with different chemical structures, the optimized nanoparticle NPF13-5 mediates the most efficient silencing of prohibitin 1, inhibition of cell proliferation, and induction of cell apoptosis towards A549 lung adenocarcinoma cells.

源语言	英语
页（从-至）	758-762
页数	5
期刊	Biomaterials Science
卷	8
期	3
DOI	https://doi.org/10.1039/c9bm01738k
出版状态	已出版 - 20 2月 2020
已对外发布	是

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10.1039/c9bm01738k

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abstract = "Six cationic lipidoid fluorodendrimers are synthesized to construct hybrid lipid-polymer nanoparticles for siRNA delivery. By screening the nanoplatforms including fluorodendrimers with different chemical structures, the optimized nanoparticle NPF13-5 mediates the most efficient silencing of prohibitin 1, inhibition of cell proliferation, and induction of cell apoptosis towards A549 lung adenocarcinoma cells.",

author = "Qingqing Xiong and Yujing Li and Kun Zhou and Ping Chen and Hua Guo and Lu Chen and Jianxun Ding and Tianqiang Song and Jinjun Shi",

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AU - Xiong, Qingqing

AU - Li, Yujing

AU - Zhou, Kun

AU - Chen, Ping

AU - Guo, Hua

AU - Chen, Lu

AU - Ding, Jianxun

AU - Song, Tianqiang

AU - Shi, Jinjun

PY - 2020/2/20

Y1 - 2020/2/20

N2 - Six cationic lipidoid fluorodendrimers are synthesized to construct hybrid lipid-polymer nanoparticles for siRNA delivery. By screening the nanoplatforms including fluorodendrimers with different chemical structures, the optimized nanoparticle NPF13-5 mediates the most efficient silencing of prohibitin 1, inhibition of cell proliferation, and induction of cell apoptosis towards A549 lung adenocarcinoma cells.

AB - Six cationic lipidoid fluorodendrimers are synthesized to construct hybrid lipid-polymer nanoparticles for siRNA delivery. By screening the nanoplatforms including fluorodendrimers with different chemical structures, the optimized nanoparticle NPF13-5 mediates the most efficient silencing of prohibitin 1, inhibition of cell proliferation, and induction of cell apoptosis towards A549 lung adenocarcinoma cells.

UR - https://www.scopus.com/pages/publications/85079019576

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DO - 10.1039/c9bm01738k

M3 - Article

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JO - Biomaterials Science

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Optimized fluorodendrimer-incorporated hybrid lipid-polymer nanoparticles for efficient siRNA delivery

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