New synthetic method of 4-[4-(3-pyridinyl)-1H-imidazol-1-yl]-1-butanamine

Zhi Ling Cao; Guo Wei Yao; Jian Hua Liang; Xin Lin Yang

New synthetic method of 4-[4-(3-pyridinyl)-1H-imidazol-1-yl]-1-butanamine

Zhi Ling Cao^*
, Guo Wei Yao
, Jian Hua Liang
, Xin Lin Yang

^*此作品的通讯作者

化学与化工学院

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

摘要

A new method was studied to synthesize 4-[4-(3-pyridinyl)-1H-imidazol-1-yl]-1-butanamine. 4(5)-(3-pyridyl)imidazole sodium salt was obtained from 3-(α-aminoacetyl)pyridine hydrochloride by formylation, cyclization and deprotonation. 4-[4-(3-pyridinyl)-1H-imidazol-1-yl]-1-butanamine was then synthesized via condensation of 4(5)-(3-pyridyl)imidazole sodium salt with N-(4-bromobutyl)phthalimide followed by hydrazinolysis. The gross yield is 54%. The new synthetic method is practical and efficient for its mild reaction conditions and the features of high yield and high purity.

源语言	英语
页（从-至）	33-36
页数	4
期刊	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
卷	27
期	SUPPL. 2
出版状态	已出版 - 12月 2007

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@article{dc51b57dcf934d59bce84944d6d0fa95,

title = "New synthetic method of 4-[4-(3-pyridinyl)-1H-imidazol-1-yl]-1-butanamine",

abstract = "A new method was studied to synthesize 4-[4-(3-pyridinyl)-1H-imidazol-1-yl]-1-butanamine. 4(5)-(3-pyridyl)imidazole sodium salt was obtained from 3-(α-aminoacetyl)pyridine hydrochloride by formylation, cyclization and deprotonation. 4-[4-(3-pyridinyl)-1H-imidazol-1-yl]-1-butanamine was then synthesized via condensation of 4(5)-(3-pyridyl)imidazole sodium salt with N-(4-bromobutyl)phthalimide followed by hydrazinolysis. The gross yield is 54\%. The new synthetic method is practical and efficient for its mild reaction conditions and the features of high yield and high purity.",

keywords = "4(5)-(3-pyridyl) imidazole, 4-[4-(3-pyridinyl)-1H-imidazol-1-yl]-1-butanamine, Synthesis, Telithromycin",

author = "Cao, \{Zhi Ling\} and Yao, \{Guo Wei\} and Liang, \{Jian Hua\} and Yang, \{Xin Lin\}",

year = "2007",

month = dec,

language = "English",

volume = "27",

pages = "33--36",

journal = "Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology",

issn = "1001-0645",

publisher = "Beijing Institute of Technology",

number = "SUPPL. 2",

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TY - JOUR

T1 - New synthetic method of 4-[4-(3-pyridinyl)-1H-imidazol-1-yl]-1-butanamine

AU - Cao, Zhi Ling

AU - Yao, Guo Wei

AU - Liang, Jian Hua

AU - Yang, Xin Lin

PY - 2007/12

Y1 - 2007/12

N2 - A new method was studied to synthesize 4-[4-(3-pyridinyl)-1H-imidazol-1-yl]-1-butanamine. 4(5)-(3-pyridyl)imidazole sodium salt was obtained from 3-(α-aminoacetyl)pyridine hydrochloride by formylation, cyclization and deprotonation. 4-[4-(3-pyridinyl)-1H-imidazol-1-yl]-1-butanamine was then synthesized via condensation of 4(5)-(3-pyridyl)imidazole sodium salt with N-(4-bromobutyl)phthalimide followed by hydrazinolysis. The gross yield is 54%. The new synthetic method is practical and efficient for its mild reaction conditions and the features of high yield and high purity.

AB - A new method was studied to synthesize 4-[4-(3-pyridinyl)-1H-imidazol-1-yl]-1-butanamine. 4(5)-(3-pyridyl)imidazole sodium salt was obtained from 3-(α-aminoacetyl)pyridine hydrochloride by formylation, cyclization and deprotonation. 4-[4-(3-pyridinyl)-1H-imidazol-1-yl]-1-butanamine was then synthesized via condensation of 4(5)-(3-pyridyl)imidazole sodium salt with N-(4-bromobutyl)phthalimide followed by hydrazinolysis. The gross yield is 54%. The new synthetic method is practical and efficient for its mild reaction conditions and the features of high yield and high purity.

KW - 4(5)-(3-pyridyl) imidazole

KW - 4-[4-(3-pyridinyl)-1H-imidazol-1-yl]-1-butanamine

KW - Synthesis

KW - Telithromycin

UR - https://www.scopus.com/pages/publications/40749141566

M3 - Article

AN - SCOPUS:40749141566

SN - 1001-0645

VL - 27

SP - 33

EP - 36

JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

IS - SUPPL. 2

ER -

New synthetic method of 4-[4-(3-pyridinyl)-1H-imidazol-1-yl]-1-butanamine

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