@inproceedings{faa4c5dcf74942298f3d6c1d8ffdd48d,
title = "Nanopost Array Integrated Digital Microfluidics for Exosome Enrichment and Molecular Ionization",
abstract = "This study presents a nanopost array-embedded digital microfluidic (DMF) platform combined with laser desorption ionization (LDI) mass spectrometry (MS) for the enrichment and direct ionization of exosomes. The nanopost array, surface-modified with functional antibodies, is embedded in the top substrate of the DMF chip, enabling the automated isolation of exosomes from samples in low volumes (<2 μ L). The enriched exosomes on the nanoposts are then subjected to laser pulses, which resonate with the array to produce ionized exosomal molecules. The established platform has achieved a limit of detection (LOD) of 10-7 mol/ L for verapamil. This method allows for direct molecular analysis of DMF-processed samples by MS, offering an efficient and streamlined approach for bioclinical applications, particularly in exosome analysis.",
keywords = "Digital Microfluidics, Exosome, Mass Spectrometry, Nanopost Array",
author = "Liyuan Guo and Menglei Zhao and Boyu Li and Bin Fu and Rongxin Fu and Kangfu Chen and Hang Li and Shuailong Zhang",
note = "Publisher Copyright: {\textcopyright} 2026 IEEE.; 39th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2026 ; Conference date: 25-01-2026 Through 29-01-2026",
year = "2026",
doi = "10.1109/MEMS64181.2026.11419372",
language = "English",
series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "1587--1590",
booktitle = "2026 IEEE 39th International Conference on Micro Electro Mechanical Systems, MEMS 2026",
address = "United States",
}