Nano-Silver-Selenium Liquid Dressing Facilitates Treatment of Monkeypox and Prevention of Viral Transmission in a Surrogate Mouse Model

Wei Wang; Mengjun Li; Zining Liu; Jiayin Chen; Ke Liu; Fengfang Wei; Junrui Li; Yixuan Xie; Yushan Jiang; Tyuji Hoshino; Vladislav Victorovich Khrustalev; Minghui Yang; Hua Ma; Ruilin Zhang; Chenguang Shen; Yuhui Liao

doi:10.1002/EXP.20240253

Nano-Silver-Selenium Liquid Dressing Facilitates Treatment of Monkeypox and Prevention of Viral Transmission in a Surrogate Mouse Model

Wei Wang
, Mengjun Li
, Zining Liu
, Jiayin Chen
, Ke Liu
, Fengfang Wei
, Junrui Li
, Yixuan Xie
, Yushan Jiang
, Tyuji Hoshino
, Vladislav Victorovich Khrustalev
, Minghui Yang^*
, Hua Ma^*
, Ruilin Zhang^*
, Chenguang Shen^*
, Yuhui Liao^*

^*此作品的通讯作者

Kunming Medical College
Southern Medical University
Putian University
Hainan Medical College Affiliated Danzhou People's Hospital
Chiba University
Belarusian State Medical University
Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

摘要

The recent monkeypox (MPOX) outbreak has drawn heightened international concern; however, no effective therapeutic interventions or reliable strategies to prevent its spread are currently available. Here, we developed a nano-silver (Ag)-selenium (Se) liquid dressing (lll) by conjugating Ag and Se nanoparticles with a commercial liquid dressing. After administration to the lesion sites, this unique formulation demonstrated highly effective antiviral properties in a surrogate MPOX mouse model (characterised by skin lesions/rashes) induced by vaccinia virus infection. In addition, AgSe@LD showed pronounced anti-inflammatory activity and accelerated the healing process of virus-infected cutaneous lesions. Remarkably, AgSe@LD formed a thin film that exhibited excellent adhesion and stability when applied to lesions, while showing resistance to water, alcohol and soapy water washing, thus offering great potential for practical application. This simple and effective liquid dressing represents a major breakthrough in the management of skin infections and provides new ideas for the treatment of MPOX.

源语言	英语
文章编号	20240253
期刊	Exploration
卷	6
期	3
DOI	https://doi.org/10.1002/EXP.20240253
出版状态	已出版 - 6月 2026
已对外发布	是

访问文件

10.1002/EXP.20240253

其它文件与链接

链接到 Scopus 的出版物

引用此

Wang, W., Li, M., Liu, Z., Chen, J., Liu, K., Wei, F., Li, J., Xie, Y., Jiang, Y., Hoshino, T., Khrustalev, V. V., Yang, M., Ma, H., Zhang, R., Shen, C., & Liao, Y. (2026). Nano-Silver-Selenium Liquid Dressing Facilitates Treatment of Monkeypox and Prevention of Viral Transmission in a Surrogate Mouse Model. Exploration, 6(3), 文章 20240253. https://doi.org/10.1002/EXP.20240253

@article{84edf4c1f09547e5b98da136ac24b9ae,

title = "Nano-Silver-Selenium Liquid Dressing Facilitates Treatment of Monkeypox and Prevention of Viral Transmission in a Surrogate Mouse Model",

abstract = "The recent monkeypox (MPOX) outbreak has drawn heightened international concern; however, no effective therapeutic interventions or reliable strategies to prevent its spread are currently available. Here, we developed a nano-silver (Ag)-selenium (Se) liquid dressing (lll) by conjugating Ag and Se nanoparticles with a commercial liquid dressing. After administration to the lesion sites, this unique formulation demonstrated highly effective antiviral properties in a surrogate MPOX mouse model (characterised by skin lesions/rashes) induced by vaccinia virus infection. In addition, AgSe@LD showed pronounced anti-inflammatory activity and accelerated the healing process of virus-infected cutaneous lesions. Remarkably, AgSe@LD formed a thin film that exhibited excellent adhesion and stability when applied to lesions, while showing resistance to water, alcohol and soapy water washing, thus offering great potential for practical application. This simple and effective liquid dressing represents a major breakthrough in the management of skin infections and provides new ideas for the treatment of MPOX.",

keywords = "antiviral therapy, liquid dressing, monkeypox, nano-silver-selenium, transmission blockage",

author = "Wei Wang and Mengjun Li and Zining Liu and Jiayin Chen and Ke Liu and Fengfang Wei and Junrui Li and Yixuan Xie and Yushan Jiang and Tyuji Hoshino and Khrustalev, \{Vladislav Victorovich\} and Minghui Yang and Hua Ma and Ruilin Zhang and Chenguang Shen and Yuhui Liao",

note = "Publisher Copyright: {\textcopyright} 2026 The Author(s). Exploration published by Henan University and John Wiley \& Sons Australia, Ltd.",

year = "2026",

month = jun,

doi = "10.1002/EXP.20240253",

language = "English",

volume = "6",

journal = "Exploration",

issn = "2766-8509",

publisher = "John Wiley and Sons Inc",

number = "3",

}

TY - JOUR

T1 - Nano-Silver-Selenium Liquid Dressing Facilitates Treatment of Monkeypox and Prevention of Viral Transmission in a Surrogate Mouse Model

AU - Wang, Wei

AU - Li, Mengjun

AU - Liu, Zining

AU - Chen, Jiayin

AU - Liu, Ke

AU - Wei, Fengfang

AU - Li, Junrui

AU - Xie, Yixuan

AU - Jiang, Yushan

AU - Hoshino, Tyuji

AU - Khrustalev, Vladislav Victorovich

AU - Yang, Minghui

AU - Ma, Hua

AU - Zhang, Ruilin

AU - Shen, Chenguang

AU - Liao, Yuhui

PY - 2026/6

Y1 - 2026/6

N2 - The recent monkeypox (MPOX) outbreak has drawn heightened international concern; however, no effective therapeutic interventions or reliable strategies to prevent its spread are currently available. Here, we developed a nano-silver (Ag)-selenium (Se) liquid dressing (lll) by conjugating Ag and Se nanoparticles with a commercial liquid dressing. After administration to the lesion sites, this unique formulation demonstrated highly effective antiviral properties in a surrogate MPOX mouse model (characterised by skin lesions/rashes) induced by vaccinia virus infection. In addition, AgSe@LD showed pronounced anti-inflammatory activity and accelerated the healing process of virus-infected cutaneous lesions. Remarkably, AgSe@LD formed a thin film that exhibited excellent adhesion and stability when applied to lesions, while showing resistance to water, alcohol and soapy water washing, thus offering great potential for practical application. This simple and effective liquid dressing represents a major breakthrough in the management of skin infections and provides new ideas for the treatment of MPOX.

AB - The recent monkeypox (MPOX) outbreak has drawn heightened international concern; however, no effective therapeutic interventions or reliable strategies to prevent its spread are currently available. Here, we developed a nano-silver (Ag)-selenium (Se) liquid dressing (lll) by conjugating Ag and Se nanoparticles with a commercial liquid dressing. After administration to the lesion sites, this unique formulation demonstrated highly effective antiviral properties in a surrogate MPOX mouse model (characterised by skin lesions/rashes) induced by vaccinia virus infection. In addition, AgSe@LD showed pronounced anti-inflammatory activity and accelerated the healing process of virus-infected cutaneous lesions. Remarkably, AgSe@LD formed a thin film that exhibited excellent adhesion and stability when applied to lesions, while showing resistance to water, alcohol and soapy water washing, thus offering great potential for practical application. This simple and effective liquid dressing represents a major breakthrough in the management of skin infections and provides new ideas for the treatment of MPOX.

KW - antiviral therapy

KW - liquid dressing

KW - monkeypox

KW - nano-silver-selenium

KW - transmission blockage

UR - https://www.scopus.com/pages/publications/105040380540

U2 - 10.1002/EXP.20240253

DO - 10.1002/EXP.20240253

M3 - Article

AN - SCOPUS:105040380540

SN - 2766-8509

VL - 6

JO - Exploration

JF - Exploration

IS - 3

M1 - 20240253

ER -

Nano-Silver-Selenium Liquid Dressing Facilitates Treatment of Monkeypox and Prevention of Viral Transmission in a Surrogate Mouse Model

摘要

访问文件

其它文件与链接

指纹

引用此