Morita–Baylis–Hillman adducts as effective dipolarophiles in Copper(i)-catalyzed 1,3-dipolar cycloaddition with azomethine ylides: Asymmetric construction of pyrrolidine derivatives containing quaternary stereogenic center

Huai Long Teng; He Huang; Hai Yan Tao; Chun Jiang Wang

doi:10.1039/c1cc11138h

Morita–Baylis–Hillman adducts as effective dipolarophiles in Copper(i)-catalyzed 1,3-dipolar cycloaddition with azomethine ylides: Asymmetric construction of pyrrolidine derivatives containing quaternary stereogenic center

Huai Long Teng
, He Huang
, Hai Yan Tao
, Chun Jiang Wang^*

^*此作品的通讯作者

Wuhan University
CAS - Shanghai Institute of Organic Chemistry

科研成果: 期刊稿件 › 文章 › 同行评审

48 引用（Scopus）

摘要

The first catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides with easily accessible Morita–Baylis–Hillman adducts as the dipolarophiles has been developed successfully and provides the highly substituted pyrrolidines bearing a unique quaternary and two tertiary stereogenic centers in excellent diastereoselectivity and up to 97% ee.

源语言	英语
页（从-至）	5494-5496
页数	3
期刊	Chemical Communications
卷	47
期	19
DOI	https://doi.org/10.1039/c1cc11138h
出版状态	已出版 - 26 4月 2011
已对外发布	是

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10.1039/c1cc11138h

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title = "Morita{\textendash}Baylis{\textendash}Hillman adducts as effective dipolarophiles in Copper(i)-catalyzed 1,3-dipolar cycloaddition with azomethine ylides: Asymmetric construction of pyrrolidine derivatives containing quaternary stereogenic center",

abstract = "The first catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides with easily accessible Morita{\textendash}Baylis{\textendash}Hillman adducts as the dipolarophiles has been developed successfully and provides the highly substituted pyrrolidines bearing a unique quaternary and two tertiary stereogenic centers in excellent diastereoselectivity and up to 97\% ee.",

author = "Teng, \{Huai Long\} and He Huang and Tao, \{Hai Yan\} and Wang, \{Chun Jiang\}",

year = "2011",

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day = "26",

doi = "10.1039/c1cc11138h",

language = "English",

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journal = "Chemical Communications",

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Teng, HL, Huang, H, Tao, HY & Wang, CJ 2011, 'Morita–Baylis–Hillman adducts as effective dipolarophiles in Copper(i)-catalyzed 1,3-dipolar cycloaddition with azomethine ylides: Asymmetric construction of pyrrolidine derivatives containing quaternary stereogenic center', Chemical Communications, 卷 47, 号码 19, 页码 5494-5496. https://doi.org/10.1039/c1cc11138h

Morita–Baylis–Hillman adducts as effective dipolarophiles in Copper(i)-catalyzed 1,3-dipolar cycloaddition with azomethine ylides: Asymmetric construction of pyrrolidine derivatives containing quaternary stereogenic center. / Teng, Huai Long; Huang, He; Tao, Hai Yan 等.
在: Chemical Communications, 卷 47, 号码 19, 26.04.2011, 页码 5494-5496.

科研成果: 期刊稿件 › 文章 › 同行评审

TY - JOUR

T1 - Morita–Baylis–Hillman adducts as effective dipolarophiles in Copper(i)-catalyzed 1,3-dipolar cycloaddition with azomethine ylides

T2 - Asymmetric construction of pyrrolidine derivatives containing quaternary stereogenic center

AU - Teng, Huai Long

AU - Huang, He

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AB - The first catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides with easily accessible Morita–Baylis–Hillman adducts as the dipolarophiles has been developed successfully and provides the highly substituted pyrrolidines bearing a unique quaternary and two tertiary stereogenic centers in excellent diastereoselectivity and up to 97% ee.

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DO - 10.1039/c1cc11138h

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