Mild Michael addition of glycine imines to aromatic nitroalkenes catalyzed by DBU with LiOTf as an additive

Wei Li; Han Liu; Da Ming Du

doi:10.1055/s-0028-1088210

Mild Michael addition of glycine imines to aromatic nitroalkenes catalyzed by DBU with LiOTf as an additive

Wei Li
, Han Liu
, Da Ming Du^*

^*此作品的通讯作者

化学与化工学院

Peking University

科研成果: 期刊稿件 › 文章 › 同行评审

13 引用（Scopus）

摘要

A mild Michael addition of glycine imines to aromatic-nitroalkenes catalyzed by 10 mol% DBU with LiOTf as an additive was developed. In most cases, the products could be obtained in good yields (up to 96%) with moderate to good diastereoselectivities (up to 10:1). The selectivity for syn adduct can be reversed to anti when the R group of glycine imines was changed from methyl or ethyl to tert-butyl.

源语言	英语
页（从-至）	925-928
页数	4
期刊	Synlett
期	6
DOI	https://doi.org/10.1055/s-0028-1088210
出版状态	已出版 - 2009

访问文件

10.1055/s-0028-1088210

其它文件与链接

链接到 Scopus 的出版物

引用此

@article{7740ff1349274051890c567f0f203837,

title = "Mild Michael addition of glycine imines to aromatic nitroalkenes catalyzed by DBU with LiOTf as an additive",

abstract = "A mild Michael addition of glycine imines to aromatic-nitroalkenes catalyzed by 10 mol\% DBU with LiOTf as an additive was developed. In most cases, the products could be obtained in good yields (up to 96\%) with moderate to good diastereoselectivities (up to 10:1). The selectivity for syn adduct can be reversed to anti when the R group of glycine imines was changed from methyl or ethyl to tert-butyl.",

keywords = "Amino acids, Catalysis, DBU, Michael addition, Nitroalkene",

author = "Wei Li and Han Liu and Du, \{Da Ming\}",

year = "2009",

doi = "10.1055/s-0028-1088210",

language = "English",

pages = "925--928",

journal = "Synlett",

issn = "0936-5214",

publisher = "Georg Thieme Verlag",

number = "6",

}

TY - JOUR

T1 - Mild Michael addition of glycine imines to aromatic nitroalkenes catalyzed by DBU with LiOTf as an additive

AU - Li, Wei

AU - Liu, Han

AU - Du, Da Ming

PY - 2009

Y1 - 2009

N2 - A mild Michael addition of glycine imines to aromatic-nitroalkenes catalyzed by 10 mol% DBU with LiOTf as an additive was developed. In most cases, the products could be obtained in good yields (up to 96%) with moderate to good diastereoselectivities (up to 10:1). The selectivity for syn adduct can be reversed to anti when the R group of glycine imines was changed from methyl or ethyl to tert-butyl.

AB - A mild Michael addition of glycine imines to aromatic-nitroalkenes catalyzed by 10 mol% DBU with LiOTf as an additive was developed. In most cases, the products could be obtained in good yields (up to 96%) with moderate to good diastereoselectivities (up to 10:1). The selectivity for syn adduct can be reversed to anti when the R group of glycine imines was changed from methyl or ethyl to tert-butyl.

KW - Amino acids

KW - Catalysis

KW - DBU

KW - Michael addition

KW - Nitroalkene

UR - https://www.scopus.com/pages/publications/63849333390

U2 - 10.1055/s-0028-1088210

DO - 10.1055/s-0028-1088210

M3 - Article

AN - SCOPUS:63849333390

SN - 0936-5214

SP - 925

EP - 928

JO - Synlett

JF - Synlett

IS - 6

ER -

Mild Michael addition of glycine imines to aromatic nitroalkenes catalyzed by DBU with LiOTf as an additive

摘要

访问文件

其它文件与链接

学术指纹

引用此