Macrophage-Instructed Intracellular Staphylococcus aureus Killing by Targeting Photodynamic Dimers

Qian Cai; Yue Fei; Hong Wei An; Xiao Xiao Zhao; Yang Ma; Yong Cong; Liming Hu; Li Li Li; Hao Wang

doi:10.1021/acsami.7b19056

Macrophage-Instructed Intracellular Staphylococcus aureus Killing by Targeting Photodynamic Dimers

Qian Cai
, Yue Fei
, Hong Wei An
, Xiao Xiao Zhao
, Yang Ma
, Yong Cong
, Liming Hu^*
, Li Li Li^*
, Hao Wang^*

^*此作品的通讯作者

College of Life Science and Bioengineering
Beijing University of Technology
National Center for Nanoscience and Technology

科研成果: 期刊稿件 › 快报 › 同行评审

71 引用（Scopus）

摘要

The survival of Staphylococcus aureus inside phagocytes is considered to be the sticking point of long-term chronic inflammation. Here, we fabricate peptide–chlorophyll-based photodynamic therapy (PDT) agents with “sandwich” dimeric structure to enhance the PDT effect and active targeting property to eliminate intracellular infections, which could be seen as prospective antibacterial agents for inflammation.

源语言	英语
页（从-至）	9197-9202
页数	6
期刊	ACS Applied Materials and Interfaces
卷	10
期	11
DOI	https://doi.org/10.1021/acsami.7b19056
出版状态	已出版 - 21 3月 2018
已对外发布	是

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10.1021/acsami.7b19056

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title = "Macrophage-Instructed Intracellular Staphylococcus aureus Killing by Targeting Photodynamic Dimers",

abstract = "The survival of Staphylococcus aureus inside phagocytes is considered to be the sticking point of long-term chronic inflammation. Here, we fabricate peptide{\textendash}chlorophyll-based photodynamic therapy (PDT) agents with {\textquotedblleft}sandwich{\textquotedblright} dimeric structure to enhance the PDT effect and active targeting property to eliminate intracellular infections, which could be seen as prospective antibacterial agents for inflammation.",

keywords = "antibacterial agent, chlorophyll, infection, peptide, photodynamic therapy",

author = "Qian Cai and Yue Fei and An, \{Hong Wei\} and Zhao, \{Xiao Xiao\} and Yang Ma and Yong Cong and Liming Hu and Li, \{Li Li\} and Hao Wang",

note = "Publisher Copyright: Copyright {\textcopyright} 2018 American Chemical Society",

year = "2018",

month = mar,

day = "21",

doi = "10.1021/acsami.7b19056",

language = "English",

volume = "10",

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journal = "ACS Applied Materials and Interfaces",

issn = "1944-8244",

publisher = "American Chemical Society",

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}

TY - JOUR

T1 - Macrophage-Instructed Intracellular Staphylococcus aureus Killing by Targeting Photodynamic Dimers

AU - Cai, Qian

AU - Fei, Yue

AU - An, Hong Wei

AU - Zhao, Xiao Xiao

AU - Ma, Yang

AU - Cong, Yong

AU - Hu, Liming

AU - Li, Li Li

AU - Wang, Hao

PY - 2018/3/21

Y1 - 2018/3/21

N2 - The survival of Staphylococcus aureus inside phagocytes is considered to be the sticking point of long-term chronic inflammation. Here, we fabricate peptide–chlorophyll-based photodynamic therapy (PDT) agents with “sandwich” dimeric structure to enhance the PDT effect and active targeting property to eliminate intracellular infections, which could be seen as prospective antibacterial agents for inflammation.

AB - The survival of Staphylococcus aureus inside phagocytes is considered to be the sticking point of long-term chronic inflammation. Here, we fabricate peptide–chlorophyll-based photodynamic therapy (PDT) agents with “sandwich” dimeric structure to enhance the PDT effect and active targeting property to eliminate intracellular infections, which could be seen as prospective antibacterial agents for inflammation.

KW - antibacterial agent

KW - chlorophyll

KW - infection

KW - peptide

KW - photodynamic therapy

UR - https://www.scopus.com/pages/publications/85044175667

U2 - 10.1021/acsami.7b19056

DO - 10.1021/acsami.7b19056

M3 - Letter

C2 - 29443494

AN - SCOPUS:85044175667

SN - 1944-8244

VL - 10

SP - 9197

EP - 9202

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 11

ER -

Macrophage-Instructed Intracellular Staphylococcus aureus Killing by Targeting Photodynamic Dimers

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