Level of DNA topoisomerase IIα mRNA predicts the treatment response of relapsed acute leukemic patients

Yan Hua Wang; Minoko Takanashi; Kazue Tsuji; Norina Tanaka; Masayuki Shiseki; Naoki Mori; Toshiko Motoji

doi:10.1016/j.leukres.2008.12.012

Level of DNA topoisomerase IIα mRNA predicts the treatment response of relapsed acute leukemic patients

Yan Hua Wang
, Minoko Takanashi
, Kazue Tsuji
, Norina Tanaka
, Masayuki Shiseki
, Naoki Mori
, Toshiko Motoji^*

^*此作品的通讯作者

Tokyo Women's Medical University
Japanese Red Cross Tokyo Blood Center

科研成果: 期刊稿件 › 文章 › 同行评审

9 引用（Scopus）

摘要

The DNA topoisomerase IIα (Topo IIα) is known as a target enzyme for many chemotherapeutic agents. We investigated the Topo IIα mRNA expression by real-time RT-PCR in 37 paired samples at diagnosis and at relapse of acute leukemic patients in relation to drug sensitivity and clinical outcome. The Topo IIα levels in leukemic blasts at relapse were significantly higher than that at diagnosis, especially in ALL. The increase in the Topo IIα level at relapse was significant in cases which could not achieve a second remission, but not significant in cases which achieved a second remission. These results suggest that the change of Topo IIα expression in leukemic blasts at relapse may predict therapeutic responsiveness.

源语言	英语
页（从-至）	902-907
页数	6
期刊	Leukemia Research
卷	33
期	7
DOI	https://doi.org/10.1016/j.leukres.2008.12.012
出版状态	已出版 - 7月 2009
已对外发布	是

联合国可持续发展目标

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可持续发展目标 3 良好健康与福祉

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10.1016/j.leukres.2008.12.012

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title = "Level of DNA topoisomerase IIα mRNA predicts the treatment response of relapsed acute leukemic patients",

abstract = "The DNA topoisomerase IIα (Topo IIα) is known as a target enzyme for many chemotherapeutic agents. We investigated the Topo IIα mRNA expression by real-time RT-PCR in 37 paired samples at diagnosis and at relapse of acute leukemic patients in relation to drug sensitivity and clinical outcome. The Topo IIα levels in leukemic blasts at relapse were significantly higher than that at diagnosis, especially in ALL. The increase in the Topo IIα level at relapse was significant in cases which could not achieve a second remission, but not significant in cases which achieved a second remission. These results suggest that the change of Topo IIα expression in leukemic blasts at relapse may predict therapeutic responsiveness.",

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author = "Wang, \{Yan Hua\} and Minoko Takanashi and Kazue Tsuji and Norina Tanaka and Masayuki Shiseki and Naoki Mori and Toshiko Motoji",

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T1 - Level of DNA topoisomerase IIα mRNA predicts the treatment response of relapsed acute leukemic patients

AU - Wang, Yan Hua

AU - Takanashi, Minoko

AU - Tsuji, Kazue

AU - Tanaka, Norina

AU - Shiseki, Masayuki

AU - Mori, Naoki

AU - Motoji, Toshiko

PY - 2009/7

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AB - The DNA topoisomerase IIα (Topo IIα) is known as a target enzyme for many chemotherapeutic agents. We investigated the Topo IIα mRNA expression by real-time RT-PCR in 37 paired samples at diagnosis and at relapse of acute leukemic patients in relation to drug sensitivity and clinical outcome. The Topo IIα levels in leukemic blasts at relapse were significantly higher than that at diagnosis, especially in ALL. The increase in the Topo IIα level at relapse was significant in cases which could not achieve a second remission, but not significant in cases which achieved a second remission. These results suggest that the change of Topo IIα expression in leukemic blasts at relapse may predict therapeutic responsiveness.

KW - Acute leukemia

KW - DNA topoisomerase IIα (Topo IIα)

KW - Drug sensitivity

KW - Multidrug resistance (MDR)

KW - Real-time RT-PCR

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U2 - 10.1016/j.leukres.2008.12.012

DO - 10.1016/j.leukres.2008.12.012

M3 - Article

C2 - 19185918

AN - SCOPUS:67349162929

SN - 0145-2126

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SP - 902

EP - 907

JO - Leukemia Research

JF - Leukemia Research

IS - 7

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Level of DNA topoisomerase IIα mRNA predicts the treatment response of relapsed acute leukemic patients

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