@inproceedings{c587184260f0432bb4483aecc157270e,
title = "Influence of topological constraints on differentiation and alignment of multinucleated myotubes",
abstract = "Due to the sensitivity to the microenvironment, stem cell-like primary muscle cells have been left behind despite their great potential in medication and tissue engineering. In this study, we successfully manipulated and maintained primary muscle cells, skeletal muscle progenitor cells (SMPs), in in vitro microfluidic models to investigate the maturity of multinucleated myotubes and the effect of topological constraints on morphology of the cells during growing and differentiating. The investigation reveals that narrower arrangement of the constraints more effectively guides the alignment of the cells, while wider arrangement of dashed wall constraints more influences the maturation of the cells.",
keywords = "Alignment, Maturation, Microfluidics, Skeletal muscle progenitor cells",
author = "Song, \{Ki Young\} and Jorge Correia and Ruas, \{Gorge L.\} and Teixeira, \{Ana I.\}",
note = "Publisher Copyright: {\textcopyright} 2019 CBMS-0001.; 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 ; Conference date: 27-10-2019 Through 31-10-2019",
year = "2019",
language = "English",
series = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019",
publisher = "Chemical and Biological Microsystems Society",
pages = "207--208",
booktitle = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019",
}