Hollow Microneedle Electrode Array (HMEA): A Tool for Drug Delivery and Low-Voltage Electroporation in Vivo

Xiaoyong Tang; Pengfei Wu; Dongxu Ma; Zixiao Yu; Yuxing Pang; Yuxuan Chen; Yingjie Ren; Zhongyan Wang; Xiaoyi Shi; Zigang Ge; Yuanyu Huang; Jingquan Liu; Zhitong Zhang; Zhihong Li

doi:10.1109/MEMS64181.2026.11419457

Hollow Microneedle Electrode Array (HMEA): A Tool for Drug Delivery and Low-Voltage Electroporation in Vivo

Xiaoyong Tang
, Pengfei Wu
, Dongxu Ma
, Zixiao Yu
, Yuxing Pang
, Yuxuan Chen
, Yingjie Ren
, Zhongyan Wang
, Xiaoyi Shi
, Zigang Ge
, Yuanyu Huang
, Jingquan Liu
, Zhitong Zhang^*
, Zhihong Li^*

^*此作品的通讯作者

Peking University
Beijing Institute of Technology
Shanghai Jiao Tong University
Zhongguancun Academy

科研成果: 书/报告/会议事项章节 › 会议稿件 › 同行评审

摘要

In this work, we report a novel tool for drug delivery and in vivo electroporation using a hollow microneedle electrode array (HMEA). The hollow microneedles are used for drug delivery and also serve as electrodes for electroporation, eliminating the cumbersome steps in traditional techniques where drugs are pre-administered with a syringe and then electroporation is performed with microneedle electrodes. The HMEA is more flexible and enables painless drug delivery. The electroporation voltage is applied on the microneedle body, avoiding the drawbacks of existing techniques where electrodes are implanted into the body through minimally invasive surgery and the voltage is conducted within the body. The HMEA is convenient to operate and safe. Additionally, the microneedles are fabricated through 3D printing and can be customized for both superficial and deep tissues with different electroporation regions. The microneedles can penetrate the stratum corneum, reducing resistance and enabling drug delivery through electroporation at low voltages. All these advantages offer great potential for practical clinical applications.

源语言	英语
主期刊名	2026 IEEE 39th International Conference on Micro Electro Mechanical Systems, MEMS 2026
出版商	Institute of Electrical and Electronics Engineers Inc.
页	478-481
页数	4
ISBN（电子版）	9798331572518
DOI	https://doi.org/10.1109/MEMS64181.2026.11419457
出版状态	已出版 - 2026
已对外发布	是
活动	39th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2026 - Salzburg, 奥地利期限: 25 1月 2026 → 29 1月 2026

出版系列

姓名	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN（印刷版）	1084-6999

会议

会议	39th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2026
国家/地区	奥地利
市	Salzburg
时期	25/01/26 → 29/01/26

访问文件

10.1109/MEMS64181.2026.11419457

其它文件与链接

链接到 Scopus 的出版物

引用此

Tang, X., Wu, P., Ma, D., Yu, Z., Pang, Y., Chen, Y., Ren, Y., Wang, Z., Shi, X., Ge, Z., Huang, Y., Liu, J., Zhang, Z., & Li, Z. (2026). Hollow Microneedle Electrode Array (HMEA): A Tool for Drug Delivery and Low-Voltage Electroporation in Vivo. 在 2026 IEEE 39th International Conference on Micro Electro Mechanical Systems, MEMS 2026 (页码 478-481). (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMS64181.2026.11419457

Tang, Xiaoyong ; Wu, Pengfei ; Ma, Dongxu 等. / Hollow Microneedle Electrode Array (HMEA) : A Tool for Drug Delivery and Low-Voltage Electroporation in Vivo. 2026 IEEE 39th International Conference on Micro Electro Mechanical Systems, MEMS 2026. Institute of Electrical and Electronics Engineers Inc., 2026. 页码 478-481 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

@inproceedings{8aeda5ef055c4dea9a4d60fdca7207f8,

title = "Hollow Microneedle Electrode Array (HMEA): A Tool for Drug Delivery and Low-Voltage Electroporation in Vivo",

abstract = "In this work, we report a novel tool for drug delivery and in vivo electroporation using a hollow microneedle electrode array (HMEA). The hollow microneedles are used for drug delivery and also serve as electrodes for electroporation, eliminating the cumbersome steps in traditional techniques where drugs are pre-administered with a syringe and then electroporation is performed with microneedle electrodes. The HMEA is more flexible and enables painless drug delivery. The electroporation voltage is applied on the microneedle body, avoiding the drawbacks of existing techniques where electrodes are implanted into the body through minimally invasive surgery and the voltage is conducted within the body. The HMEA is convenient to operate and safe. Additionally, the microneedles are fabricated through 3D printing and can be customized for both superficial and deep tissues with different electroporation regions. The microneedles can penetrate the stratum corneum, reducing resistance and enabling drug delivery through electroporation at low voltages. All these advantages offer great potential for practical clinical applications.",

keywords = "Drug delivery, Electrode array, Electroporation, Hollow microneedle",

author = "Xiaoyong Tang and Pengfei Wu and Dongxu Ma and Zixiao Yu and Yuxing Pang and Yuxuan Chen and Yingjie Ren and Zhongyan Wang and Xiaoyi Shi and Zigang Ge and Yuanyu Huang and Jingquan Liu and Zhitong Zhang and Zhihong Li",

note = "Publisher Copyright: {\textcopyright} 2026 IEEE.; 39th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2026 ; Conference date: 25-01-2026 Through 29-01-2026",

year = "2026",

doi = "10.1109/MEMS64181.2026.11419457",

language = "English",

series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "478--481",

booktitle = "2026 IEEE 39th International Conference on Micro Electro Mechanical Systems, MEMS 2026",

address = "United States",

}

Tang, X, Wu, P, Ma, D, Yu, Z, Pang, Y, Chen, Y, Ren, Y, Wang, Z, Shi, X, Ge, Z, Huang, Y, Liu, J, Zhang, Z & Li, Z 2026, Hollow Microneedle Electrode Array (HMEA): A Tool for Drug Delivery and Low-Voltage Electroporation in Vivo. 在 2026 IEEE 39th International Conference on Micro Electro Mechanical Systems, MEMS 2026. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), Institute of Electrical and Electronics Engineers Inc., 页码 478-481, 39th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2026, Salzburg, 奥地利, 25/01/26. https://doi.org/10.1109/MEMS64181.2026.11419457

Hollow Microneedle Electrode Array (HMEA): A Tool for Drug Delivery and Low-Voltage Electroporation in Vivo. / Tang, Xiaoyong; Wu, Pengfei; Ma, Dongxu 等.
2026 IEEE 39th International Conference on Micro Electro Mechanical Systems, MEMS 2026. Institute of Electrical and Electronics Engineers Inc., 2026. 页码 478-481 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

科研成果: 书/报告/会议事项章节 › 会议稿件 › 同行评审

TY - GEN

T1 - Hollow Microneedle Electrode Array (HMEA)

T2 - 39th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2026

AU - Tang, Xiaoyong

AU - Wu, Pengfei

AU - Ma, Dongxu

AU - Yu, Zixiao

AU - Pang, Yuxing

AU - Chen, Yuxuan

AU - Ren, Yingjie

AU - Wang, Zhongyan

AU - Shi, Xiaoyi

AU - Ge, Zigang

AU - Huang, Yuanyu

AU - Liu, Jingquan

AU - Zhang, Zhitong

AU - Li, Zhihong

PY - 2026

Y1 - 2026

N2 - In this work, we report a novel tool for drug delivery and in vivo electroporation using a hollow microneedle electrode array (HMEA). The hollow microneedles are used for drug delivery and also serve as electrodes for electroporation, eliminating the cumbersome steps in traditional techniques where drugs are pre-administered with a syringe and then electroporation is performed with microneedle electrodes. The HMEA is more flexible and enables painless drug delivery. The electroporation voltage is applied on the microneedle body, avoiding the drawbacks of existing techniques where electrodes are implanted into the body through minimally invasive surgery and the voltage is conducted within the body. The HMEA is convenient to operate and safe. Additionally, the microneedles are fabricated through 3D printing and can be customized for both superficial and deep tissues with different electroporation regions. The microneedles can penetrate the stratum corneum, reducing resistance and enabling drug delivery through electroporation at low voltages. All these advantages offer great potential for practical clinical applications.

AB - In this work, we report a novel tool for drug delivery and in vivo electroporation using a hollow microneedle electrode array (HMEA). The hollow microneedles are used for drug delivery and also serve as electrodes for electroporation, eliminating the cumbersome steps in traditional techniques where drugs are pre-administered with a syringe and then electroporation is performed with microneedle electrodes. The HMEA is more flexible and enables painless drug delivery. The electroporation voltage is applied on the microneedle body, avoiding the drawbacks of existing techniques where electrodes are implanted into the body through minimally invasive surgery and the voltage is conducted within the body. The HMEA is convenient to operate and safe. Additionally, the microneedles are fabricated through 3D printing and can be customized for both superficial and deep tissues with different electroporation regions. The microneedles can penetrate the stratum corneum, reducing resistance and enabling drug delivery through electroporation at low voltages. All these advantages offer great potential for practical clinical applications.

KW - Drug delivery

KW - Electrode array

KW - Electroporation

KW - Hollow microneedle

UR - https://www.scopus.com/pages/publications/105041710421

U2 - 10.1109/MEMS64181.2026.11419457

DO - 10.1109/MEMS64181.2026.11419457

M3 - Conference contribution

AN - SCOPUS:105041710421

T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

SP - 478

EP - 481

BT - 2026 IEEE 39th International Conference on Micro Electro Mechanical Systems, MEMS 2026

PB - Institute of Electrical and Electronics Engineers Inc.

Y2 - 25 January 2026 through 29 January 2026

ER -

Tang X, Wu P, Ma D, Yu Z, Pang Y, Chen Y 等. Hollow Microneedle Electrode Array (HMEA): A Tool for Drug Delivery and Low-Voltage Electroporation in Vivo. 在 2026 IEEE 39th International Conference on Micro Electro Mechanical Systems, MEMS 2026. Institute of Electrical and Electronics Engineers Inc. 2026. 页码 478-481. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMS64181.2026.11419457

Hollow Microneedle Electrode Array (HMEA): A Tool for Drug Delivery and Low-Voltage Electroporation in Vivo

摘要

出版系列

会议

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引用此