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High-throughput peptide screening on a bimodal imprinting chip through ms-spri integration

  • Weizhi Wang
  • , Qiaojun Fang
  • , Zhiyuan Hu

科研成果: 书/报告/会议事项章节章节同行评审

摘要

Screening of high affinity and high specificity peptide probes towards various targets is important in the biomedical field while traditional peptide screening procedure is manual and tedious. Herein, a bimodal imprinting microarray system to embrace the whole peptide screening process is presented. Surface Plasmon Resonance imaging (SPRi) and matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS) are combined for both quantitative and qualitative identification of the peptide. The method provides a solution for high efficiency peptide screening.

源语言英语
主期刊名Methods in Molecular Biology
出版商Humana Press Inc.
111-125
页数15
DOI
出版状态已出版 - 2016
已对外发布

出版系列

姓名Methods in Molecular Biology
1352
ISSN(印刷版)1064-3745

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