GH79 家族糖苷水解酶分子进化关系和蛋白结构研究

The glycoside hydrolases of the GH79 family have extensive physiological activities and important application prospects in carbohydrate modification, cellular immune recognition and signal transduction. However, the diverse catalysis mechanism of GH79 family remains unclear, and the structural basis and molecular mechanism of substrate recognition are still unclear. This review summarizes the research progress of the GH79 family, systematically analyzes the origin and distribution of GH79 family enzymes, and deeply expounds their sequence features, molecular evolutionary relationships, and the crystal structures analysis, aiming to lay a foundation for protein engineering and functional metabolic mechanism of GH79 family.