TY - JOUR
T1 - Evoking Photothermy by Capturing Intramolecular Bond Stretching Vibration-Induced Dark-State Energy
AU - Chen, Ming
AU - Zhang, Xiaoyan
AU - Liu, Junkai
AU - Liu, Feng
AU - Zhang, Ruoyao
AU - Wei, Peifa
AU - Feng, Haitao
AU - Tu, Mei
AU - Qin, Anjun
AU - Lam, Jacky W.Y.
AU - Ding, Dan
AU - Tang, Ben Zhong
PY - 2020/4/28
Y1 - 2020/4/28
N2 - Development of highly effective approaches to desirable photothermal conversion agents is particularly valuable. Herein, we report a concept, namely, bond stretching vibration-induced photothermy, that serves as a mechanism to construct advanced photothermal conversion agents. As a proof-of-concept, two compounds (DCP-TPA and DCP-PTPA) with donor-acceptor (D-A) structures were synthesized. The bond stretching vibration of the pyrazine-containing unit in these molecules is vigorous and insensitive to the external environmental restraint, which efficiently transforms the absorbed photons to dark-state heat energy. The nanoparticles (NPs) of DCP-TPA and DCP-PTPA show rather high photothermal conversion efficiency (52% and 59%) and stronger photoacoustic (PA) signal than commercial methylene blue and reported high-performance semiconducting polymer nanoparticles. The DCP-PTPA NPs perform better than DCP-TPA NPs in terms of photothermal conversion, PA signal production, and in vivo PA tumor imaging because of the increased bond stretching vibration in the former molecule.
AB - Development of highly effective approaches to desirable photothermal conversion agents is particularly valuable. Herein, we report a concept, namely, bond stretching vibration-induced photothermy, that serves as a mechanism to construct advanced photothermal conversion agents. As a proof-of-concept, two compounds (DCP-TPA and DCP-PTPA) with donor-acceptor (D-A) structures were synthesized. The bond stretching vibration of the pyrazine-containing unit in these molecules is vigorous and insensitive to the external environmental restraint, which efficiently transforms the absorbed photons to dark-state heat energy. The nanoparticles (NPs) of DCP-TPA and DCP-PTPA show rather high photothermal conversion efficiency (52% and 59%) and stronger photoacoustic (PA) signal than commercial methylene blue and reported high-performance semiconducting polymer nanoparticles. The DCP-PTPA NPs perform better than DCP-TPA NPs in terms of photothermal conversion, PA signal production, and in vivo PA tumor imaging because of the increased bond stretching vibration in the former molecule.
KW - intramolecular bond stretching vibration
KW - near-infrared absorption
KW - photoacoustic tumor imaging
KW - photothermal conversion
KW - pyrazine-containing electron acceptor
UR - https://www.scopus.com/pages/publications/85084167407
U2 - 10.1021/acsnano.9b09625
DO - 10.1021/acsnano.9b09625
M3 - Article
C2 - 32160460
AN - SCOPUS:85084167407
SN - 1936-0851
VL - 14
SP - 4265
EP - 4275
JO - ACS Nano
JF - ACS Nano
IS - 4
ER -