Eremophilane sesquiterpenes from Hawaiian endophytic fungus Chaetoconis sp. FT087

Chun Shun Li; Yuanqing Ding; Bao Jun Yang; Naomi Hoffman; Hong Quan Yin; Taifo Mahmud; James Turkson; Shugeng Cao

doi:10.1016/j.phytochem.2016.03.005

Eremophilane sesquiterpenes from Hawaiian endophytic fungus Chaetoconis sp. FT087

Chun Shun Li
, Yuanqing Ding
, Bao Jun Yang
, Naomi Hoffman
, Hong Quan Yin
, Taifo Mahmud
, James Turkson
, Shugeng Cao^*

^*此作品的通讯作者

University of Hawai'i at Hilo
University of Hawai'i at Mānoa
University of Mississippi
Honolulu Botanical Garden
Oregon State University

科研成果: 期刊稿件 › 文章 › 同行评审

30 引用（Scopus）

摘要

Seven sesquiterpene derivatives, including chaetopenoids A-F and dendryphiellin A₁, and 6-methyl-(2E, 4E, 6S) octadienoic acid were isolated from the culture broth of Chaetoconis sp. FT087. Their structures were determined through the analysis of HRMS and NMR spectroscopic data. The absolute configurations of chaetopenoids A-D were elucidated by comparison of their CD and optical rotation data with those in the literature. Chaetopenoids A-C and E belong to the eremophilane type of sesquiterpenoids, while chaetopenoids D and F and dendryphiellin A₁ have a trinor-eremophilane skeleton. All compounds were tested against A2780 and cisplatin resistant A2780CisR cell lines, and dendryphiellin A₁ was moderately active with IC₅₀ values of 6.6 and 9.1 μg/mL, respectively.

源语言	英语
页（从-至）	41-46
页数	6
期刊	Phytochemistry
卷	126
DOI	https://doi.org/10.1016/j.phytochem.2016.03.005
出版状态	已出版 - 6月 2016
已对外发布	是

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@article{283c4ef070594be49e919f65e88ba4ca,

title = "Eremophilane sesquiterpenes from Hawaiian endophytic fungus Chaetoconis sp. FT087",

abstract = "Seven sesquiterpene derivatives, including chaetopenoids A-F and dendryphiellin A1, and 6-methyl-(2E, 4E, 6S) octadienoic acid were isolated from the culture broth of Chaetoconis sp. FT087. Their structures were determined through the analysis of HRMS and NMR spectroscopic data. The absolute configurations of chaetopenoids A-D were elucidated by comparison of their CD and optical rotation data with those in the literature. Chaetopenoids A-C and E belong to the eremophilane type of sesquiterpenoids, while chaetopenoids D and F and dendryphiellin A1 have a trinor-eremophilane skeleton. All compounds were tested against A2780 and cisplatin resistant A2780CisR cell lines, and dendryphiellin A1 was moderately active with IC50 values of 6.6 and 9.1 μg/mL, respectively.",

keywords = "Araliaceae, Bioactivity, Chaetoconis sp. FT087, Endophytic fungi, Hawai'i, Osmoxylon novoguineensis, Sesquiterpenes",

author = "Li, \{Chun Shun\} and Yuanqing Ding and Yang, \{Bao Jun\} and Naomi Hoffman and Yin, \{Hong Quan\} and Taifo Mahmud and James Turkson and Shugeng Cao",

year = "2016",

month = jun,

doi = "10.1016/j.phytochem.2016.03.005",

language = "English",

volume = "126",

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journal = "Phytochemistry",

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TY - JOUR

T1 - Eremophilane sesquiterpenes from Hawaiian endophytic fungus Chaetoconis sp. FT087

AU - Li, Chun Shun

AU - Ding, Yuanqing

AU - Yang, Bao Jun

AU - Hoffman, Naomi

AU - Yin, Hong Quan

AU - Mahmud, Taifo

AU - Turkson, James

AU - Cao, Shugeng

PY - 2016/6

Y1 - 2016/6

N2 - Seven sesquiterpene derivatives, including chaetopenoids A-F and dendryphiellin A1, and 6-methyl-(2E, 4E, 6S) octadienoic acid were isolated from the culture broth of Chaetoconis sp. FT087. Their structures were determined through the analysis of HRMS and NMR spectroscopic data. The absolute configurations of chaetopenoids A-D were elucidated by comparison of their CD and optical rotation data with those in the literature. Chaetopenoids A-C and E belong to the eremophilane type of sesquiterpenoids, while chaetopenoids D and F and dendryphiellin A1 have a trinor-eremophilane skeleton. All compounds were tested against A2780 and cisplatin resistant A2780CisR cell lines, and dendryphiellin A1 was moderately active with IC50 values of 6.6 and 9.1 μg/mL, respectively.

AB - Seven sesquiterpene derivatives, including chaetopenoids A-F and dendryphiellin A1, and 6-methyl-(2E, 4E, 6S) octadienoic acid were isolated from the culture broth of Chaetoconis sp. FT087. Their structures were determined through the analysis of HRMS and NMR spectroscopic data. The absolute configurations of chaetopenoids A-D were elucidated by comparison of their CD and optical rotation data with those in the literature. Chaetopenoids A-C and E belong to the eremophilane type of sesquiterpenoids, while chaetopenoids D and F and dendryphiellin A1 have a trinor-eremophilane skeleton. All compounds were tested against A2780 and cisplatin resistant A2780CisR cell lines, and dendryphiellin A1 was moderately active with IC50 values of 6.6 and 9.1 μg/mL, respectively.

KW - Araliaceae

KW - Bioactivity

KW - Chaetoconis sp. FT087

KW - Endophytic fungi

KW - Hawai'i

KW - Osmoxylon novoguineensis

KW - Sesquiterpenes

UR - https://www.scopus.com/pages/publications/84961132271

U2 - 10.1016/j.phytochem.2016.03.005

DO - 10.1016/j.phytochem.2016.03.005

M3 - Article

C2 - 26995148

AN - SCOPUS:84961132271

SN - 0031-9422

VL - 126

SP - 41

EP - 46

JO - Phytochemistry

JF - Phytochemistry

ER -

Eremophilane sesquiterpenes from Hawaiian endophytic fungus Chaetoconis sp. FT087

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